Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus

被引:24
作者
Sakamoto, Fumie [1 ]
Katakami, Naoto [1 ,2 ]
Kaneto, Hideaki [1 ]
Yasuda, Tetsuyuki [1 ]
Takahara, Mitsuyoshi [1 ]
Miyashita, Kazuyuki [1 ]
Kuroda, Akio [3 ]
Matsuhisa, Munehide [3 ]
Kosugi, Keisuke [4 ]
Shimomura, Iichiro [1 ]
机构
[1] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan
[3] Univ Tokushima, Diabet Clin Res & Dev Ctr, Tokushima 7708503, Japan
[4] Osaka Police Hosp, Dept Internal Med, Osaka 5430035, Japan
关键词
YKL-40; Type; 1; diabetes; Albuminuria; Diabetic retinopathy; ENDOTHELIAL DYSFUNCTION; PLASMA YKL-40; MICROVASCULAR COMPLICATIONS; CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE; INFLAMMATION; NEPHROPATHY; MARKERS; RISK; EPIDEMIOLOGY;
D O I
10.1507/endocrj.EJ12-0238
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
YICL-40 is a marker of inflammation and endothelial dysfunction, both of which play important roles in the progression of diabetic complications. However, little information has been obtained about serum YKL-40 levels in type 1 diabetic patients. We evaluated YICL-40 levels and its association with diabetic micro- and macroandgiopathy in 131 young Japanese type 1 diabetic patients without advanced diabetic complications (aged 24.7 +/- 5.9 years) and 97 age- and gender-matched healthy controls. YKL-40 levels were significantly elevated in type 1 diabetic patients than in healthy controls (median (range) 46.4 (20.3-136.7) and 52.3 (21.4-274.1) ng/ml, respectively, p = 0.003). There was a significant positive association between YKL-40 levels and urinary albumin creatinine ratio (UACR) (r = 0.226, p = 0.013). Furthermore, a multivariate regression analysis demonstrated that YKL-40 levels were a determinant of UACR independently of conventional risk factors. In addition, YKL-40 levels were significantly higher in participants with diabetic retinopathy compared to those without it (median (range) 55.5 (23.3-274.1) and 50.3 (21.4-237.4) ng/ml, respectively, p = 0.039). Serum YICL-40 levels were elevated in type 1 diabetic patients and associated with increasing level of albuminuria. YKL-40 could be a predictor to assess the risk of diabetic microangiopathy in the early stage in type 1 diabetic patients.
引用
收藏
页码:73 / 79
页数:7
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