Low EphA7 Expression Correlated with Lymph Node Metastasis and Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma

被引：15

作者：

Bai, Yu-Qin ^{[1
,4
]}

Zhang, Jun-Yi ^{[1
,4
]}

Bai, Chun-Ying ^{[2
,4
]}

Xu, Xiu-E ^{[4
,5
]}

Wu, Jian-Yi ^{[4
,6
]}

Chen, Bo ^{[4
,5
]}

Wu, Zhi-Yong ^{[4
,7
]}

Wang, Shao-Hong ^{[4
,8
]}

Shen, Jian ^{[4
,5
]}

Shen, Jin-Hui ^{[4
,8
]}

Yao, Xiao-Dong ^{[4
,7
]}

Gao, Lian-Zhu ^{[9
]}

Wu, Bao ^{[3
]}

Gu, Hong-Li ^{[10
]}

Liu, Xiao-Hui ^{[1
]}

Li, Xin ^{[1
]}

Li, En-Min ^{[4
]}

Xu, Li-Yan ^{[4
]}

机构：

[1] Chifeng Univ, Coll Med, Dept Pathol, Chifeng 024000, Peoples R China

[2] Chifeng Univ, Coll Med, Res Ctr Mol Med, Chifeng 024000, Peoples R China

[3] Chifeng Univ, Coll Med, Dept Histol & Embryol, Chifeng 024000, Peoples R China

[4] Shantou Univ, Coll Med, Key Lab Mol Biol High Canc Incidence Coastal Chao, Shantou 515041, Peoples R China

[5] Shantou Univ, Coll Med, Inst Oncol Pathol, Shantou 515041, Peoples R China

[6] Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou 515041, Peoples R China

[7] Sun Yat Sen Univ, Affiliated Shantou Hosp, Shantou Cent Hosp, Dept Pathol, Shantou 515041, Peoples R China

[8] Sun Yat Sen Univ, Affiliated Shantou Hosp, Shantou Cent Hosp, Oncol Surg, Shantou 515041, Peoples R China

[9] Second Hosp Chifeng City, Dept Pathol, Chifeng 024000, Peoples R China

[10] Chifeng Univ, Affiliated Hosp, Dept Pediat, Chifeng 024000, Peoples R China

来源：

ACTA HISTOCHEMICA ET CYTOCHEMICA | 2015年 / 48卷 / 03期

关键词：

EphA7; esophageal squamous cell carcinoma; lymph mode metastasis; immunohistochemistry; prognosis; RECEPTOR TYROSINE KINASE; NERVOUS-SYSTEM; CANCER; LIGANDS; EPHRINS; GENE; FEATURES; DISEASE; PATTERN; MARKERS;

D O I：

10.1267/ahc.14054

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As a member of the Eph family of receptor tyrosine kinases, EphA7 plays an important role in cancer. However, the expression and significance of Eph receptors in esophageal squamous cell carcinoma (ESCC) remain unclear. Here, we detected the expression of EphA7 by immunohistochemistry in a sample of 352 patients with ESCC, and aimed to investigate the expression status of EphA7 in ESCC and its impact on prognosis. The results showed that low EphA7 expression significantly correlated with lymph node metastases (N0: 29%; N1: 64%. p<0.001), poor degree of tumor differentiation (G1: 31%; G2: 49%; G3: 58%. p=0.009) and pTNM staging (I+II: 33%; III+IV: 58%. p<0.001). Furthermore, in a combined analysis, patients with low EphA7-expressing tumors showed a shorter overall survival than those with high expression, resulting in a five-year overall survival rate of 47.4% vs. 52.6%, respectively (p=0.016). Consequently, patients with a low EphA7 expression have poorer prognosis in ESCC compared with those manifesting high expression.

引用

页码：75 / 81

页数：7

共 34 条

[1] Should en bloc esophagectomy be the standard of care for esophageal carcinoma? [J].

Altorki, N ;

Skinner, D .

ANNALS OF SURGERY, 2001, 234 (05) :581-587

[2]

[Anonymous], 2010, WHO Classification of tumors of the digestive system

[3] The expression of chick EphA7 during segmentation of the central and peripheral nervous system [J].

Araujo, M ;

Nieto, MA .

MECHANISMS OF DEVELOPMENT, 1997, 68 (1-2) :173-177

[4] Tyrosine phosphorylation of transmembrane ligands for Eph receptors [J].

Bruckner, K ;

Pasquale, EB ;

Klein, R .

SCIENCE, 1997, 275 (5306) :1640-1643

[5]

CIOSSEK T, 1995, ONCOGENE, V10, P97

[6]

Committee E., 1997, CELL, V90, P403

[7]

Edge S.B., 2010, AJCC cancer staging manual, V649

[8] Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application [J].

Fox, BP ;

Kandpal, RP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 318 (04) :882-892

[9] Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development [J].

Gale, NW ;

Yancopoulos, GD .

GENES & DEVELOPMENT, 1999, 13 (09) :1055-1066

[10] Ephrins and Eph receptors in stem cells and cancer [J].

Genander, Maria ;

Frisen, Jonas .

CURRENT OPINION IN CELL BIOLOGY, 2010, 22 (05) :611-616

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