Analyses of anticancer drugs by capillary electrophoresis: a review

被引：55

作者：

Ali, Imran ^{[1
]}

Haque, Ashanul ^{[1
]}

Wani, Waseem A. ^{[1
]}

Saleem, Kishwar ^{[1
]}

Al Za'abi, Mohammed ^{[2
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

[2] Sultan Qaboos Univ, Dept Pharmacol & Clin Pharm, Coll Med & Hlth Sci, Muscat, Oman

来源：

BIOMEDICAL CHROMATOGRAPHY | 2013年 / 27卷 / 10期

关键词：

capillary electrophoresis; anticancer drugs; biological samples; future perspectives; POTENTIAL TUMOR-MARKERS; DNA METHYLATION; BREAST-CANCER; HUMAN PLASMA; SIMULTANEOUS QUANTIFICATION; ZONE-ELECTROPHORESIS; URINARY NUCLEOSIDES; PROTEIN-BINDING; VINCA ALKALOIDS; GASTRIC-CANCER;

D O I：

10.1002/bmc.2953

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Capillary electrophoresis is a fast, inexpensive and low detection limit technique for the analysis of anticancer drugs. It has been used to analyze various anticancer drugs in biological samples, pharmaceutical preparations and environmental matrices. It has also been used to detect various cancer biomarkers in cancer patients. The present article describes the state-of-the art of capillary electrophoresis for the analyses of anticancer drugs. Various drugs discussed belong to several groups such as antimitotic agents, nucleoside analogs, antibiotics, topoisomerase inhibitors and DNA intercalating agents. In addition, efforts have also been made to discuss sample preparation, applications of capillary electrophoresis in genomic research, optimization and future perspectives. Copyright (c) 2013 John Wiley & Sons, Ltd.

引用

页码：1296 / 1311

页数：16

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