Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives

被引:3
|
作者
Kulig, Katarzyna [1 ]
Rybicka, Karolina [1 ]
Malawska, Barbara [1 ]
机构
[1] Jagiellonian Univ, Coll Med, Dept Physicochem Drug Anal, Chair Pharmaceut Chem,Fac Pharm, PL-30688 Krakow, Poland
关键词
dissociation constants; pK(a); RP-TLC; potentiometric titration; pyrrolidin-2-one derivatives;
D O I
10.1002/bmc.1048
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The procedures for measuring dissociation constants (pK(a)) of twenty 1-substituted pyrrolidin-2-one derivatives are described. The dissociation constants of the compounds tested were determined using potentiometric titration, reversed-phase thin-layer chromatography (RP-TLC) and calculated using Pallas and Marvin programs. It was found that the RP-TLC method of determination of pK(a) could be considered as a feasible alternative to potentiometric titration. The Marvin program is a better tool for preliminary estimation of dissociation constant than the Pallas one. Copyright (c) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码:1225 / 1229
页数:5
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