Application of RP-TLC technique for the determination of dissociation constants of 1-substituted pyrrolidin-2-one derivatives

被引：3
|
作者：
Kulig, Katarzyna [1 ]
Rybicka, Karolina [1 ]
Malawska, Barbara [1 ]
机构：
[1] Jagiellonian Univ, Coll Med, Dept Physicochem Drug Anal, Chair Pharmaceut Chem,Fac Pharm, PL-30688 Krakow, Poland
来源：
BIOMEDICAL CHROMATOGRAPHY | 2008年 / 22卷 / 11期
关键词：
dissociation constants; pK(a); RP-TLC; potentiometric titration; pyrrolidin-2-one derivatives;
D O I：
10.1002/bmc.1048
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The procedures for measuring dissociation constants (pK(a)) of twenty 1-substituted pyrrolidin-2-one derivatives are described. The dissociation constants of the compounds tested were determined using potentiometric titration, reversed-phase thin-layer chromatography (RP-TLC) and calculated using Pallas and Marvin programs. It was found that the RP-TLC method of determination of pK(a) could be considered as a feasible alternative to potentiometric titration. The Marvin program is a better tool for preliminary estimation of dissociation constant than the Pallas one. Copyright (c) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：1225 / 1229
页数：5
相关论文
共 50 条
  • [1] RP-TLC Determination of the Lipophilicity of 1-Substituted Pyrrolidin-2-one Derivatives. Correlation of Lipophilicity with Affinity for α-Adrenoceptors
    Kulig, Katarzyna
    Malawska, Barbara
    JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2009, 22 (02) : 141 - 144
  • [2] RP-TLC Determination of the Lipophilicity of 1-Substituted Pyrrolidin-2-one Derivatives. Correlation of Lipophilicity with Affinity for α-Adrenoceptors
    Katarzyna Kulig
    Barbara Malawska
    JPC – Journal of Planar Chromatography – Modern TLC, 2009, 22 : 141 - 144
  • [3] Estimation of the lipophilicity of antiarrhythmic and antihypertensive active 1-substituted pyrrolidin-2-one and pyrrolidine derivatives
    Kulig, K
    Malawska, B
    BIOMEDICAL CHROMATOGRAPHY, 2003, 17 (05) : 318 - 324
  • [4] Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity
    Malawska, B
    Kulig, K
    Filipek, B
    Sapa, J
    Maciag, D
    Zygmunt, M
    Antkiewicz-Michaluk, L
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (03) : 183 - 195
  • [5] A new asymmetric approach toward 5-substituted pyrrolidin-2-one derivatives
    Poli, G
    Ciofi-Baffoni, S
    Giambastiani, G
    Reginato, G
    TETRAHEDRON, 1998, 54 (35) : 10403 - 10418
  • [6] RP-TLC determination of the lipophilicity of some new derivatives of 1,2,4-triazole and thiosemicarbazide with potential antituberculosis activity
    Flieger, J
    Tatarczak, M
    Wujec, M
    Pitucha, M
    Szumilo, H
    JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2006, 19 (107) : 32 - 41
  • [7] RP-TLC Determination of the Lipophilicity of Some New Derivatives of 1,2,4-Triazole and Thiosemicarbazide with Potential Antituberculosis Activity
    J. Flieger
    M. Tatarczak
    M. Wujec
    M. Pitucha
    H. Szumiło
    JPC – Journal of Planar Chromatography – Modern TLC, 2006, 19 : 32 - 41
  • [8] Synthesis of 3,3- and 4,4-Alkyl-phenyl-substituted Pyrrolidin-2-one Derivatives
    Kulig, K.
    Ignasik, M.
    Malawska, B.
    POLISH JOURNAL OF CHEMISTRY, 2009, 83 (09) : 1629 - 1636
  • [9] Design and Synthesis of Tri-substituted Chiral Pyrrolidin-2-one Derivatives as CCR4 Antagonists
    Sun, Wei
    Tian, Linjie
    Qi, Hui
    Jiang, Dan
    Wang, Ying
    Li, Song
    Xiao, Junhai
    Yang, Xiaohong
    CHINESE JOURNAL OF CHEMISTRY, 2013, 31 (09) : 1144 - 1152
  • [10] Separation of 4C-Substituted Pyrrolidin-2-One Derivatives on Amylose-Based Chiral Stationary Phases
    Kazoka, Helena
    Turovska, Baiba
    Upmanis, Toms
    Orlova, Natalja
    Vorona, Maksims
    CHROMATOGRAPHIA, 2021, 84 (07) : 663 - 675
12345