INTERPENETRATING NETWORK HYDROGEL DISCS OF POLY(VINYL ALCOHOL) AND POLY(VINYL PYRROLIDONE) FOR CONTROLLED RELEASE OF AN ANTI-DIABETIC DRUG

被引：0

作者：

Kulkarni, Raghavendra V. ^{[1
]}

More, Swapnil M. ^{[1
]}

Alange, Vijaykumar V. ^{[1
]}

Naikawade, Akram A. ^{[2
]}

Birajdar, Ravindra P. ^{[1
]}

机构：

[1] BLDEAs Coll Pharm, Dept Pharmaceut Technol, Bijapur 586103, Karnataka, India

[2] BLDE Univ Bijapur, Shri BM Patil Med Coll, Dept Pharmacol, Bijapur 586103, Karnataka, India

来源：

FARMACIA | 2013年 / 61卷 / 01期

关键词：

Hydrogel discs; Interpenetrating polymer network; Glipizide; Drug release; POLY(ACRYLIC ACID); GENTAMICIN SULFATE; POLYMER NETWORKS; IN-VITRO; GELATIN; MECHANISM; DELIVERY;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present investigation, hydrogel based interpenetrating network (IPN) discs of poly(vinyl alcohol) and poly(vinyl pyrrolidone) loaded with an anti-diabetic drug, glipizide were prepared by chemical crosslinking method. The prepared discs were characterized by thermogravimetric analysis (TGA), differential scanning calorimetric analysis (DSC) and X-ray diffractometry (XRD). The swelling behavior and drug release were dependent upon the crosslink density. The IPN hydrogel discs were capable of releasing drug up to 24 h. The discs which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.

引用

页码：66 / 78

页数：13

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