IMPACT OF IMMUNITY IN AUTISM SPECTRUM DISORDERS

被引：1

作者：

Tete, S. ^{[1
]}

Varvara, G. ^{[1
]}

Murmura, G. ^{[1
]}

Saggini, A. ^{[2
]}

Maccauro, G. ^{[3
]}

Rosati, M. ^{[4
]}

Cianchetti, E. ^{[5
]}

Tripodi, D. ^{[1
]}

Toniato, E. ^{[6
]}

Fulcheri, M. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Pandolfi, F. ^{[9
]}

Potalivo, G. ^{[8
]}

Conti, P. ^{[6
]}

Theoharides, T. C. ^{[10
,11
]}

机构：

[1] Univ Chiet Pescarai, Sch Dent, Chieti, Italy

[2] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[3] Univ Cattolica, Orthoped Div, Rome, Italy

[4] Osped Pescara, Gynecol Div, Pescara, Italy

[5] Ortona ASL Hosp, Dept Surg, Ortona, Italy

[6] Univ G dAnnunzio, Sch Med, Div Immunol, Chieti, Italy

[7] Univ G dAnnunzio, Sch Psychol, Chieti, Italy

[8] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy

[9] Univ Cattolica Sacro Cuore, Dept Med, Rome, Italy

[10] Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Mol Immunopharmacol & Drug Discovery Lab, Boston, MA 02111 USA

[11] Tufts Univ New England Med Ctr, Drug Discovery Lab, Boston, MA 02111 USA

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2013年 / 11卷 / 01期

关键词：

autism spectrum disorders; cytokines; inflammation; immunity; CORTICOTROPIN-RELEASING HORMONE; NECROSIS-FACTOR-ALPHA; MESSENGER-RNA EXPRESSION; BLOOD MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; T-CELLS; MAST-CELLS; IN-VITRO; INFLAMMATORY RESPONSE; IMMOBILIZATION STRESS;

D O I：

10.1177/1721727X1301100103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autism spectrum disorders (ASDs) are childhood psychopathologies characterized by having difficulties in social interaction, verbal and non-verbal communication as well as sensor motor movements. Evidence suggests that in ASDs environmental toxicant exposure, genetic and mitochondrial dysfunction are involved associated with abnormal immune response with allergic problems and elevated serum IgE. ASDs present the major cytokine and chemokine dysfunction in CNS and is mediated by an increase of pro-inflammatory cytokine levels in the brain, such as TNF, IL-I, IFN-gamma, IL-6, IL-8 and others. Mast cells, which are also implicated in ASDs, are worsened by stress and produce proinflammatory cytokines and can be stimulated by neurotensin in the brain and gut, contributing also to the inflammatory response. However, the exact etiology of ASDs remains largely unknown.

引用

页码：23 / 31

页数：9

共 96 条

[1] Inflammatory mediators and modulation of blood-brain barrier permeability [J].