Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions

被引：12

作者：

Takeuchi, Hikaru ^{[1
]}

Taki, Yasuyuki ^{[1
,2
,3
]}

Nouchi, Rui ^{[4
,5
,6
]}

Yokoyama, Ryoichi ^{[7
]}

Kotozaki, Yuka ^{[8
]}

Nakagawa, Seishu ^{[9
,10
]}

Sekiguchi, Atsushi ^{[2
,11
]}

Iizuka, Kunio ^{[12
]}

Yamamoto, Yuki ^{[9
]}

Hanawa, Sugiko ^{[9
]}

Araki, Tsuyoshi ^{[13
]}

Miyauchi, Carlos Makoto ^{[14
]}

Sakaki, Kohei ^{[6
]}

Nozawa, Takayuki ^{[15
]}

Ikeda, Shigeyuki ^{[16
]}

Yokota, Susumu ^{[1
]}

Daniele, Magistro ^{[17
]}

Sassa, Yuko ^{[1
]}

Kawashima, Ryuta ^{[1
,6
,9
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc, Div Dev Cognit Neurosci, Aoba Ku, 4-1 Seiryo Cho, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Tohoku Med Megabank Org, Dept Community Med Supports, Div Med Neuroimaging Anal, Sendai, Miyagi, Japan

[3] Tohoku Univ, Inst Dev Aging & Canc, Dept Radiol & Nucl Med, Sendai, Miyagi, Japan

[4] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Creat Interdisciplinary Res Div, Sendai, Miyagi, Japan

[5] Tohoku Univ, Int Res Inst Disaster Sci, Human & Social Response Res Div, Sendai, Miyagi, Japan

[6] Tohoku Univ, Inst Dev Aging & Canc, Dept Adv Brain Sci, Sendai, Miyagi, Japan

[7] Kobe Univ, Sch Med, Kobe, Hyogo, Japan

[8] Fukushima Med Univ, Sch Med, Div Clin Res, Med Ind Translat Res Ctr, Fukushima, Japan

[9] Tohoku Univ, Inst Dev Aging & Canc, Dept Human Brain Sci, Sendai, Miyagi, Japan

[10] Tohoku Med & Pharmaceut Univ, Div Psychiat, Sendai, Miyagi, Japan

[11] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, Tokyo, Japan

[12] Tohoku Univ, Grad Sch Med, Dept Psychiat, Sendai, Miyagi, Japan

[13] ADVANTAGE Risk Management Co Ltd, Tokyo, Japan

[14] Tokyo Metropolitan Univ, Grad Sch Humanities, Dept Language Sci, Tokyo, Japan

[15] Tokyo Inst Technol, Collaborat Res Ctr Happiness Cocreat Soc Intellig, Tokyo, Japan

[16] Tohoku Univ, Inst Dev Aging & Canc, Dept Ubiquitous Sensing, Sendai, Miyagi, Japan

[17] Nottingham Trent Univ, Sch Sci & Technol, Dept Sport Sci, Nottingham, England

来源：

BRAIN STRUCTURE & FUNCTION | 2019年 / 224卷 / 03期

关键词：

Copper; Regional gray matter volume; Mean diffusivity; Cognitive functions; SERUM-FREE COPPER; ALZHEIMERS-DISEASE; DOPAMINERGIC SYSTEM; SUBSTANTIA-NIGRA; OXIDATIVE STRESS; TRACE-ELEMENTS; IRON; ZINC; TOXICITY; CHILDREN;

D O I：

10.1007/s00429-019-01830-y

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Although copper plays a critical role in normal brain functions and development, it is known that excess copper causes toxicity. Here we investigated the associations of copper levels in the hair with regional gray matter volume (rGMV), mean diffusivity (MD), and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that high copper levels were associated mostly with low cognitive abilities (low scores on the intelligence test consisting of complex speed tasks, involving reasoning task, a complex arithmetic task, and a reading comprehension task) as well as lower reverse Stroop interference, high rGMV over widespread areas of the brain [mainly including the bilateral lateral and medial parietal cortices, medial temporal structures (amygdala, hippocampus, and parahippocampal gyrus), middle cingulate cortex, orbitofrontal cortex, insula, perisylvian areas, inferior temporal lobe, temporal pole, occipital lobes, and supplementary motor area], as well as high MD of the right substantia nigra and bilateral hippocampus, which are indicative of low density in brain tissues. These results suggest that copper levels are associated with mostly aberrant cognitive functions, greater rGMV in extensive areas, greater MD (which are indicative of low density in brain tissues) in subcortical structures in the healthy young adults, possibly reflecting copper's complex roles in neural mechanisms.

引用

页码：1203 / 1217

页数：15

共 93 条

[1]

[Anonymous], 1996, KIKAN SEISHINKA SHIN

[2] Voxel-based morphometry - The methods [J].