Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases

被引：17

作者：

Baidya, Falguni ^{[1
]}

Bohra, Mariya ^{[1
]}

Datta, Aishika ^{[1
]}

Sarmah, Deepaneeta ^{[1
]}

Shah, Birva ^{[1
]}

Jagtap, Priya ^{[1
]}

Raut, Swapnil ^{[1
]}

Sarkar, Ankan ^{[1
]}

Singh, Upasna ^{[1
]}

Kalia, Kiran ^{[1
]}

Borah, Anupom ^{[2
]}

Wang, Xin ^{[3
]}

Dave, Kunjan R. ^{[4
]}

Yavagal, Dileep R. ^{[5
]}

Bhattacharya, Pallab ^{[1
]}

机构：

[1] Ahmedabad NIPER A, Dept Pharmacol & Toxicol, Natl Inst Pharmaceut Educ & Res, Gandhinagar, Gujarat, India

[2] Assam Univ, Dept Life Sci & Bioinformat, Silchar, Assam, India

[3] Harvard Med Sch, Dept Neurosurg, Brigham & Womens Hosp, Boston, MA 02115 USA

[4] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[5] Univ Miami, Miller Sch Med, Dept Neurol & Neurosurg, Miami, FL 33136 USA

来源：

IMMUNOLOGY | 2021年 / 162卷 / 02期

关键词：

complement system; immune system; inflammasome; microglia; neurodegenerative disease; AMYOTROPHIC-LATERAL-SCLEROSIS; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; TRANSGENIC MOUSE MODEL; NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; COMPLEMENT ACTIVATION;

D O I：

10.1111/imm.13264

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurodegeneration is characterized by gradual onset and limited availability of specific biomarkers. Apart from various aetiologies such as infection, trauma, genetic mutation, the interaction between the immune system and CNS is widely associated with neuronal damage in neurodegenerative diseases. The immune system plays a distinct role in disease progression and cellular homeostasis. It induces cellular and humoral responses, and enables tissue repair, cellular healing and clearance of cellular detritus. Aberrant and chronic activation of the immune system can damage healthy neurons. The pro-inflammatory mediators secreted by chief innate immune components, the complement system, microglia and inflammasome can augment cytotoxicity. Furthermore, these inflammatory mediators accelerate microglial activation resulting in progressive neuronal loss. Various animal studies have been carried out to unravel the complex pathology and ascertain biomarkers for these harmful diseases, but have had limited success. The present review will provide a thorough understanding of microglial activation, complement system and inflammasome generation, which lead the healthy brain towards neurodegeneration. In addition to this, possible targets of immune components to confer a strategic treatment regime for the alleviation of neuronal damage are also summarized.

引用

页码：160 / 178

页数：19

共 259 条

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