Biomedicine - Lowering LDL - Not only how low, but how long?

被引：157

作者：

Brown, MS ^{[1
]}

Goldstein, JL ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA

来源：

SCIENCE | 2006年 / 311卷 / 5768期

关键词：

D O I：

10.1126/science.1125884

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

People with a mutation in a proteolytic enzyme are at a substantially lower risk for coronary heart disease because of their lifelong reduction of plasma low-density lipoprotein.

引用

页码：1721 / 1723

页数：3

共 23 条

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].

Abifadel, M ;

Varret, M ;

Rabès, JP ;

Allard, D ;

Ouguerram, K ;

Devillers, M ;

Cruaud, C ;

Benjannet, S ;

Wickham, L ;

Erlich, D ;

Derré, A ;

Villéger, L ;

Farnier, M ;

Beucler, I ;

Bruckert, E ;

Chambaz, J ;

Chanu, B ;

Lecerf, JM ;

Luc, G ;

Moulin, P ;

Weissenbach, J ;

Prat, A ;

Krempf, M ;

Junien, C ;

Seidah, NG ;

Boileau, C .

NATURE GENETICS, 2003, 34 (02) :154-156

[2] Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins [J].

Baigent, C ;

Keech, A ;

Kearney, PM ;

Blackwell, L ;

Buck, G ;

Pollicino, C ;

Kirby, A ;

Sourjina, T ;

Peto, R ;

Collins, R ;

Simes, J .

LANCET, 2005, 366 (9493) :1267-1278

[3] Cord blood lipoproteins and prenatal influences [J].

Bansal, N ;

Cruickshank, JK ;

McElduff, P ;

Durrington, PN .

CURRENT OPINION IN LIPIDOLOGY, 2005, 16 (04) :400-408

[4] A tribute to Akira Endo, discoverer of a "Penicillin" for cholesterol [J].

Brown, MS ;

Goldstein, JL .

ATHEROSCLEROSIS SUPPLEMENTS, 2004, 5 (03) :13-16

[5] SERUM-CHOLESTEROL CONCENTRATION AND CORONARY HEART-DISEASE IN POPULATION WITH LOW CHOLESTEROL CONCENTRATIONS [J].

CHEN, ZM ;

PETO, R ;

COLLINS, R ;

MACMAHON, S ;

LU, JR ;

LI, WX .

BRITISH MEDICAL JOURNAL, 1991, 303 (6797) :276-282

[6] Low LDL cholesterol in African Americans resulting from frequent nonsense mutations in PCSK9 [J].

Cohen, J ;

Pertsemlidis, A ;

Kotowski, IK ;

Graham, R ;

Garcia, CK ;

Hobbs, HH .

NATURE GENETICS, 2005, 37 (03) :328-328

[7] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

[8] Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia [J].

Dubuc, G ;

Chamberland, A ;

Wassef, H ;

Davignon, J ;

Seidah, NG ;

Bernier, L ;

Prat, A .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (08) :1454-1459

[9] CORONARY DISEASE AMONG UNITED-STATES SOLDIERS KILLED IN ACTION IN KOREA [J].

ENOS, WF ;

HOLMES, RH ;

BEYER, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1953, 152 (12) :1090-1093

[10]

Goldstein J., 2001, The metabolic and molecular bases of inherited disease, P2863

← 1 2 3 →