Pilot study on CHCF1 genotype in a pig challenge model for enterotoxigenic Escherichia coli F4ab/ac associated post-weaning diarrhea

被引：7
作者：
Rydal, Martin Peter [1 ]
Gambino, Michela [1 ]
Jorgensen, Claus Bottcher [1 ]
Poulsen, Louise Ladefoged [1 ]
Brondsted, Lone [1 ]
Nielsen, Jens Peter [1 ]
机构：
[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg C, Denmark
来源：
BMC VETERINARY RESEARCH | 2022年 / 18卷 / 01期
关键词：
Diarrhea; Inoculum dose; Experimental infection; Enterotoxigenic Escherichia coli; F4; fimbriae; Genetic marker; Piglet; Post-weaning; POSTWEANING DIARRHEA; VIRULENCE GENES; PREVALENCE;
D O I：
10.1186/s12917-022-03474-3
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Host genotype is important for enterotoxigenic E. coli (ETEC) susceptibility. We conducted two trials to evaluate the effect of CHCF1 genotype on incidence of ETEC diarrhea. In trial 1 (n = 15 pigs), pigs were inoculated with 10(8) CFU or 10(10) CFU doses of an ETEC F4ac strain. In trial 2 (n = 33 pigs), pigs were inoculated with ETEC F4ab or F4ac. Across trials, all inoculated pigs that developed ETEC diarrhea were CHCF1 heterozygous susceptible (6/6). No inoculated CHCF1 homozygous resistant pigs developed ETEC diarrhea (0/26). Susceptibility towards ETEC F4ac/ab infection might correspond with CHCF1 genotype.
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页数：6
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