Increased number of caveolae and caveolin-3 overexpression in Duchenne muscular dystrophy

被引：84

作者：

Repetto, S

Bado, M

Broda, P

Lucania, G

Masetti, E

Sotgia, F

Carbone, I

Pavan, A

Bonilla, E

Cordone, G

Lisanti, MP

Minetti, C

机构：

[1] Univ Genoa, Ist Gaslini, Serv Malattie Neuromuscolari, I-16147 Genoa, Italy

[2] Univ Rome La Sapienza, Dipartimento Med Sperimentale & Patol, Rome, Italy

[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[4] Univ Aquila, Dipartimento Med Sperimentale, I-67100 Laquila, Italy

[5] Columbia Univ, Dept Neurol, New York, NY USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 261卷 / 03期

关键词：

caveolae membranes; caveolin-3; Duchenne muscular dystrophy;

D O I：

10.1006/bbrc.1999.1055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolae are small pockets or invaginations localized at the plasma membrane. Caveolins are the principal protein components of caveolae and play an important structural role in the formation of caveolae membranes. Here, we studied by freeze fracture and immunological techniques the spatial organization of caveolae at the muscle cell plasma membrane and the expression of caveolin-3 in Duchenne muscular dystrophy (DMD) muscle fibers. In DMD muscle, we found an increased number of caveolae at the sarcolemma that corresponds to an overexpression of caveolin-3 by immunohistochemistry and by Western blot analysis. These findings suggest a possible role for caveolae and caveolin-3 in the pathogenesis of DMD. (C) 1999 Academic Press.

引用

页码：547 / 550

页数：4

共 17 条

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