Evolution of the Chronic Congestive Heart Failure Paradigm

被引:3
|
作者
Savino, John A., III [1 ]
Kosmas, Constantine E. [2 ]
Wagman, Gabriel [3 ]
Vittorio, Timothy J. [3 ]
机构
[1] Mt Sinai Sch Med, Dept Internal Med, New York, NY USA
[2] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA
[3] St Francis Hosp, Ctr Heart, Div Cardiol, Ctr Adv Cardiac Therapeut, Roslyn, NY 11576 USA
关键词
chronic congestive heart failure; cardiorenal; hemodynamic; neurohumoral; mechanical; metabolic; LEFT-VENTRICULAR FUNCTION; ACUTE MYOCARDIAL-INFARCTION; DILATED CARDIOMYOPATHY; ISOSORBIDE DINITRATE; CARDIAC-HYPERTROPHY; EXERCISE TOLERANCE; DOUBLE-BLIND; THERAPY; MORTALITY; TRIMETAZIDINE;
D O I
10.1097/CRD.0b013e318277c990
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Paradigms are a part of our human nature. In the world of medicine and science, they allow investigators to work within a particular, previously accepted framework that provides certain constraints. This is the crux of Newton's quote, "If I've seen so far it's because I stood upon the shoulders of giants." However, in the same way that it allows us to build, it can constrain our thought processes if we fail to accept new data that are ill suited to an accepted paradigm. The physiological mechanisms to explain the phenomenon of chronic congestive heart failure are similar to other paradigms of science, in that they have undergone several shifts throughout their history, and continue to change with new evidence. Here, we seek to explore how our understanding of congestive heart failure has changed.
引用
收藏
页码:121 / 126
页数:6
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