Electrocatalytic determination of 6-tioguanine at a p-aminophenol modified carbon paste electrode

被引：99

作者：

Mirmomtaz, Elham ^{[1
]}

Ensafi, Ali Asghar ^{[1
]}

Karimi-Maleh, Hassan ^{[1
]}

机构：

[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran

来源：

ELECTROANALYSIS | 2008年 / 20卷 / 18期

关键词：

p-aminophenol; 6-thioguanine; electrocatalysis; square-wave voltammetry; kinetic parameters;

D O I：

10.1002/elan.200804273

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A p-aminophenol modified carbon paste electrode (p-APMCPE) was constructed for determination of an anticancer drug 6-thioguanine (6-TG). The cyclic voltammogram showed that the electrocatalytic oxidation of 6-TG at the surface of p-APMCPE occurs at a potential about 840 mV less positive than at an unmodified electrode. Square-wave voltammetry results presented that the electrocatalytic oxidation peak Currents of 6-TG in pH 9.0 had two linear dynamic ranges in the range of 0.2 to 8.0 and 8.0 to 350.0 mu M 6-TG with a detection limit of 0.08 mu M. The kinetic parameters such as electron transfer coefficient (alpha) and rate constant were determined for the chemical reaction between 6-TG and p-aminophenol. Finally, this method was evaluated for the determination of 6-TG in 6-thioguanine tablets and urine samples.

引用

收藏

页码：1973 / 1979

页数：7

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