Enantioseparation of racemic organic ammonium perchlorates by a silica gel bound optically active di-tert-butylpyridino-18-crown-6 ligand

被引：38

作者：

Köntös, Z

Huszthy, P ^{[1
]}

Bradshaw, JS

Izatt, RM

机构：

[1] Hungarian Acad Sci, Res Grp Alkaloid Chem, H-1521 Budapest, Hungary

[2] Tech Univ Budapest, Inst Organ Chem, H-1521 Budapest, Hungary

[3] Brigham Young Univ, Dept Chem, Provo, UT 84602 USA

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 11期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0957-4166(99)00163-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Both enantiomers of the novel chiral di-tert-butylpyridino-18-crown-6 ligand (R,R)-7 and (S,S)-7 containing an allyloxy group on the pyridine subcyclic unit were prepared by the reaction of 4-allyloxy-2,6-pyridinedimethyl ditosylate 9 and the enantiomers of di-tert-butyl-substituted tetraethylene glycol (R,R)-8 and (S,S)-8 in the presence of a strong base. One of them, (R,R)-7, was covalently attached to silica gel, and this chiral stationary phase (CSP) separated four selected racemic organic ammonium perchlorates into their enantiomers by column chromatography. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2087 / 2099

页数：13

共 33 条

[1] DIRECT CHIRAL LIQUID-CHROMATOGRAPHIC SEPARATION OF TOCAINIDE ENANTIOMERS ON A CROWNPAK (CR) COLUMN AND ITS APPLICATION TO PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL-FLUIDS [J].