Phase-Transfer Catalysis under Continuous Flow Conditions: An Alternative Approach to the Biphasic Liquid/Liquid O-Alkylation of Phenols

被引：16
作者：
De Zani, Daniele [1 ]
Colombo, Matteo [1 ]
机构：
[1] NiKem Res, I-20021 Milan, Italy
来源：
JOURNAL OF FLOW CHEMISTRY | 2012年 / 2卷 / 01期
关键词：
alkylation; ether; flow chemistry; phase-transfer catalysis; phenol; MICROSTRUCTURED REACTORS; MICROREACTORS; NOVELTIES; CHEMISTRY;
D O I：
10.1556/jfchem.2012.00020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
O-Alkylation of phenol compounds was performed in a continuous flow apparatus under biphasic liquid/liquid conditions and promoted by tetrabutylammonium bromide (TBAB) as a phase-transfer catalyst. The segmented flow that is generated within the flow system is able to afford the desired ethers in high yield and in very short times.
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页码：5 / +
页数：8
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