Bioactives from microalgal dinoflagellates

被引:68
作者
Gallardo-Rodriguez, J. [2 ]
Sanchez-Miron, A. [2 ]
Garcia-Camacho, F. [2 ]
Lopez-Rosales, L. [2 ]
Chisti, Y. [1 ]
Molina-Grima, E. [2 ]
机构
[1] Massey Univ, Sch Engn, Palmerston North, New Zealand
[2] Univ Almeria, Dept Chem Engn, Almeria 04120, Spain
关键词
Dinoflagellates; Microalgae; Marine toxins; Shear-sensitivity; Photobioreactor; SMALL-SCALE TURBULENCE; HARMFUL ALGAL BLOOMS; POLYKETIDE SYNTHASE GENES; RED TIDE DINOFLAGELLATE; MARINE NATURAL-PRODUCTS; CELL-CYCLE ARREST; OKADAIC ACID; PARALYTIC SHELLFISH; POPULATION-GROWTH; PROTOCERATIUM-RETICULATUM;
D O I
10.1016/j.biotechadv.2012.07.005
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Dinoflagellate microalgae are an important source of marine biotoxins. Bioactives from dinoflagellates are attracting increasing attention because of their impact on the safety of seafood and potential uses in biomedical, toxicological and pharmacological research. Here we review the potential applications of dinoflagellate toxins and the methods for producing them. Only sparing quantities of dinoflagellate toxins are generally available and this hinders bioactivity characterization and evaluation in possible applications. Approaches to production of increased quantities of dinoflagellate bioactives are discussed. Although many dinoflagellates are fragile and grow slowly, controlled culture in bioreactors appears to be generally suitable for producing many of the metabolites of interest. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:1673 / 1684
页数:12
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