Respiratory rhythm generation during gasping depends on persistent sodium current

被引：167
作者：
Paton, JFR [1 ]
Abdala, APL
Koizumi, H
Smith, JC
St John, WM
机构：
[1] Univ Bristol, Sch Med Sci, Bristol Heart Inst, Dept Physiol, Bristol BS8 1TH, Avon, England
[2] NINDS, Cellular & Syst Neurobiol Sect, NIH, Bethesda, MD 20892 USA
[3] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Physiol, Lebanon, NH 03756 USA
来源：
NATURE NEUROSCIENCE | 2006年 / 9卷 / 03期
关键词：
D O I：
10.1038/nn1650
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism.
引用
收藏
页码：311 / 313
页数：3
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