The functions and unique features of long intergenic non-coding RNA

被引：1077

作者：

Ransohoff, Julia D. ^{[1
]}

Wei, Yuning ^{[1
]}

Khavari, Paul A. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA

[2] Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2018年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

X-CHROMOSOME INACTIVATION; GENOME-WIDE ANALYSIS; EMBRYONIC STEM-CELLS; OPEN READING FRAMES; GENE-EXPRESSION; MESSENGER-RNA; TRANSCRIPTIONAL ACTIVITY; XIST RNA; BINDING PROTEINS; ACTIVE CHROMATIN;

D O I：

10.1038/nrm.2017.104

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.

引用

页码：143 / 157

页数：15

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