Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease

被引：24

作者：

Tanila, Heikki ^{[1
]}

机构：

[1] Univ Eastern Finland, AI Virtanen Inst, Kuopio 70211, Finland

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2012年 / 4卷

关键词：

spatial memory; amyloid-beta; amyloid precursor protein; presenilin-1; tau; AMYLOID PRECURSOR PROTEIN; MORRIS WATER MAZE; COGNITIVE DEFICITS; SPATIAL MEMORY; APP23; MODEL; A-BETA; MICE; AGE; TASK; DEPOSITION;

D O I：

10.3389/fnagi.2012.00011

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The Morris swim navigation task ("water maze") has been a primary research tool to assess hippocampal-dependent spatial learning and memory in rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies performed with the Morris swim task in mice than in rats. The task has proved to be particularly useful in demonstrating age-related memory impairment in transgenic mouse models of Alzheimer's disease (AD). This review focuses on task details that are most relevant for its application to mouse studies in general and characteristic patterns of impaired performance in Alzheimer model mice as compared with rodents sustaining hippocampal lesions.

引用

页数：7

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