Extracellular Vesicles for Research on Psychiatric Disorders

被引：13

作者：

Kano, Shin-ichi ^{[1
]}

Dohi, Eisuke ^{[1
]}

Rose, Indigo V. L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA

来源：

SCHIZOPHRENIA BULLETIN | 2019年 / 45卷 / 01期

关键词：

extracellular vesicle; EVs; exosome; microvesicle; biomarker; intercellular communication; schizophrenia; psychiatric disorders; EXOSOME RELEASE; INTERCELLULAR COMMUNICATION; SECRETE EXOSOMES; PLASMA-MEMBRANE; FLOW-CYTOMETRY; BRAIN; CELLS; MICROVESICLES; ASTROCYTES; PROTEIN;

D O I：

10.1093/schbul/sby127

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.

引用

页码：7 / 16

页数：10

共 106 条

[1] Amyloid-β Reduces Exosome Release from Astrocytes by Enhancing JNK Phosphorylation [J].

Abdullah, Mohammad ;

Takase, Hiroshi ;

Nunome, Mari ;

Enomoto, Hiroyuki ;

Ito, Jin-ichi ;

Gong, Jian-Sheng ;

Michikawa, Makoto .

JOURNAL OF ALZHEIMERS DISEASE, 2016, 53 (04) :1433-1441

[2] Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake [J].

Abels, Erik R. ;

Breakefield, Xandra O. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016, 36 (03) :301-312

[3] Exosome-delivered microRNAs modulate the inflammatory response to endotoxin [J].

Alexander, Margaret ;

Hu, Ruozhen ;

Runtsch, Marah C. ;

Kagele, Dominique A. ;

Mosbruger, Timothy L. ;

Tolmachova, Tanya ;

Seabra, Miguel C. ;

Round, June L. ;

Ward, Diane M. ;

O'Connell, Ryan M. .

NATURE COMMUNICATIONS, 2015, 6

[4] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[5] Comparative analysis of EV isolation procedures for miRNAs detection in serum samples [J].

Andreu, Zoraida ;

Rivas, Eva ;

Sanguino-Pascual, Aitana ;

Lamana, Amalia ;

Marazuela, Monica ;

Gonzalez-Alvaro, Isidoro ;

Sanchez-Madrid, Francisco ;

de la Fuente, Hortensia ;

Yanez-Mo, Maria .

JOURNAL OF EXTRACELLULAR VESICLES, 2016, 5

[6] Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism [J].

Antonucci, Flavia ;

Turola, Elena ;

Riganti, Loredana ;

Caleo, Matteo ;

Gabrielli, Martina ;

Perrotta, Cristiana ;

Novellino, Luisa ;

Clementi, Emilio ;

Giussani, Paola ;

Viani, Paola ;

Matteoli, Michela ;

Verderio, Claudia .

EMBO JOURNAL, 2012, 31 (05) :1231-1240

[7] Depletion of microglia and inhibition of exosome synthesis halt tau propagation [J].

Asai, Hirohide ;

Ikezu, Seiko ;

Tsunoda, Satoshi ;

Medalla, Maria ;

Luebke, Jennifer ;

Haydar, Tank ;

Wolozin, Benjamin ;

Butovsky, Oleg ;

Kuegler, Sebastian ;

Ikezu, Tsuneya .

NATURE NEUROSCIENCE, 2015, 18 (11) :1584-1593

[8] Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons [J].

Ashley, James ;

Cordy, Benjamin ;

Lucia, Diandra ;

Fradkin, Lee G. ;

Budnik, Vivian ;

Thomson, Travis .

CELL, 2018, 172 (1-2) :262-+

[9] Syndecan-syntenin-ALIX regulates the biogenesis of exosomes [J].

Baietti, Maria Francesca ;

Zhang, Zhe ;

Mortier, Eva ;

Melchior, Aurelie ;

Degeest, Gisele ;

Geeraerts, Annelies ;

Ivarsson, Ylva ;

Depoortere, Fabienne ;

Coomans, Christien ;

Vermeiren, Elke ;

Zimmermann, Pascale ;

David, Guido .

NATURE CELL BIOLOGY, 2012, 14 (07) :677-685

[10] Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles [J].

Balusu, Sriram ;

Van Wonterghem, Ellen ;

De Rycke, Riet ;

Raemdonck, Koen ;

Stremersch, Stephan ;

Gevaert, Kris ;

Brkic, Marjana ;

Demeestere, Delphine ;

Vanhooren, Valerie ;

Hendrix, An ;

Libert, Claude ;

Vandenbroucke, Roosmarijn E. .

EMBO MOLECULAR MEDICINE, 2016, 8 (10) :1162-1183

← 1 2 3 4 5 6 7 8 9 10 →