Impact of Immune-Modulatory Drugs on Regulatory T Cell

被引：106

作者：

Furukawa, Akiko ^{[1
]}

Wisel, Steven A. ^{[1
]}

Tang, Qizhi ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA

来源：

TRANSPLANTATION | 2016年 / 100卷 / 11期

关键词：

RENAL-TRANSPLANT RECIPIENTS; BELATACEPT-BASED IMMUNOSUPPRESSION; ANTI-CD52; MONOCLONAL-ANTIBODY; VITAMIN-D DEFICIENCY; VERSUS-HOST-DISEASE; FACTOR-KAPPA-B; LOW-DOSE IL-2; DE-NOVO; KIDNEY-TRANSPLANTATION; ALLOGRAFT-REJECTION;

D O I：

10.1097/TP.0000000000001379

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosuppression strategies that selectively inhibit effector T cells while preserving and even enhancing CD4(+) FOXP3(+) regulatory T cells (Treg) permit immune self-regulation and may allow minimization of immunosuppression and associated toxicities. Many immunosuppressive drugs were developed before the identity and function of Treg were appreciated. A good understanding of the interactions between Treg and immunosuppressive agents will be valuable to the effective design of more tolerable immunosuppression regimens. This review will discuss preclinical and clinical evidence regarding the influence of current and emerging immunosuppressive drugs on Treg homeostasis, stability, and function as a guideline for the selection and development of Treg-friendly immunosuppressive regimens.

引用

页码：2288 / 2300

页数：13

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