A 155-dB Dynamic Range Current Measurement Front End for Electrochemical Biosensing

被引：36

作者：

Dai, Shanshan ^{[1
]}

Perera, Rukshan T. ^{[1
]}

Yang, Zi ^{[1
]}

Rosenstein, Jacob K. ^{[1
]}

机构：

[1] Brown Univ, Sch Engn, Providence, RI 02912 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS | 2016年 / 10卷 / 05期

关键词：

Amperometric; analog front end; current measurement; current to voltage converter; electrochemistry; high dynamic range; low noise; nanosensors; POTENTIOSTAT ARRAY; DESIGN; GAIN;

D O I：

10.1109/TBCAS.2016.2612581

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An integrated current measurement system with ultra wide dynamic range is presented and fabricated in a 180-nm CMOS technology. Its dual-mode design provides concurrent voltage and frequency outputs, without requiring an external clock source. An integrator-differentiator core provides a voltage output with a noise floor of 11.6 fA/root Hz and a -3 dB cutoff frequency of 1.4 MHz. It is merged with an asynchronous current-to-frequency converter, which generates an output frequency linearly proportional to the input current. Together, the voltage and frequency outputs yield a current measurement range of 155 dB, spanning from 204 fA (100 Hz) or 1.25 pA (10 kHz) to 11.6 mu A. The proposed architecture's low noise, wide bandwidth, and wide dynamic range make it ideal for measurements of highly nonlinear electrochemical and electrophysiological systems.

引用

页码：935 / 944

页数：10

共 29 条

[1]

[Anonymous], 2009, P 2009 IEEE INT SOL

[2] Electrochemical camera chip for simultaneous imaging of multiple metabolites in biofilms [J].