Free-Radical Cascade Alkylarylation of Alkenes with Simple Alkanes: Highly Efficient Access to Oxindoles via Selective (sp3)C-H and (sp2)C-H Bond Functionalization

被引：249

作者：

Li, Zejiang ^{[1
]}

Zhang, Ye ^{[1
]}

Zhang, Lizhi ^{[1
]}

Liu, Zhong-Quan ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; PD-CATALYZED OLEFINATION; ACTIVATED ALKENES; C(SP(3))-H BONDS; UNACTIVATED C(SP(3))-H; HETEROCYCLE SYNTHESIS; DIRECT ALKYLATION; COUPLING REACTION; C(SP(2))-H BONDS; TRANSITION-METAL;

D O I：

10.1021/ol4032478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed alkylarylation of alkenes with simple alkanes was achieved, which not only provided an efficient method to prepare various alkyl-substituted oxindoles, but also represented a novel strategy for selective sp(3) C-H functionalization/C-C bond formation via a free-radical cascade process. Additionally, selective activation of unactivated (sp(3))C-H and (sp(2))C-H bonds by one single step is achieved in this system, which would also provide a novel strategy for raising efficiency in C-H bond functionalization.

引用

页码：382 / 385

页数：4

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