The Effect of Vitamin A Supplementation on Retinoic Acid-Related Orphan Receptor γt (RORγt) and Interleukin-17 (IL-17) Gene Expression in Avonex-Treated Multiple Sclerotic Patients

被引：23

作者：

Honarvar, Niyaz Mohammadzadeh ^{[1
,2
]}

Harirchian, Mohammad Hossein ^{[3
]}

Koohdani, Fariba ^{[1
,2
]}

Siassi, Feridoun ^{[2
,4
]}

Abdolahi, Mina ^{[1
,2
]}

Bitarafan, Sama ^{[1
,2
]}

Salehi, Eisa ^{[5
]}

Sahraian, Mohammad Ali ^{[6
]}

Eshraghian, Mohammad Reza ^{[7
]}

Saboor-Yarghi, Ali Akbar ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Cellular & Mol Nutr Dept, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Publ Hlth, Tehran, Iran

[3] Univ Tehran Med Sci, Iranian Ctr Neurol Res, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Community Nutr Dept, Tehran, Iran

[5] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[6] Univ Tehran Med Sci, Sina Hosp, Dept Neurol, Tehran, Iran

[7] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat, Tehran, Iran

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2013年 / 51卷 / 03期

关键词：

IL-17; ROR gamma t; Multiple sclerosis; Gene expression; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CELL-DIFFERENTIATION; TH17; CELLS; METABOLISM; ACTIVATION; RESPONSES; T(H)17; SYSTEM; ALPHA;

D O I：

10.1007/s12031-013-0058-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the role of vitamin A on ROR gamma t and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and ROR gamma t gene expression. No changes in gene expression occurred in the placebo group.

引用

页码：749 / 753

页数：5

共 29 条

[1] Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis [J].