Duchenne Dilated Cardiomyopathy: Cardiac Management from Prevention to Advanced Cardiovascular Therapies

被引：36

作者：

Adorisio, Rachele ^{[1
]}

Mencarelli, Erica ^{[1
]}

Cantarutti, Nicoletta ^{[2
]}

Calvieri, Camilla ^{[2
]}

Amato, Liliana ^{[1
]}

Cicenia, Marianna ^{[2
]}

Silvetti, Massimo ^{[2
]}

D'Amico, Adele ^{[3
]}

Grandinetti, Maria ^{[1
,4
]}

Drago, Fabrizio ^{[2
]}

Amodeo, Antonio ^{[1
]}

机构：

[1] Bambino Gesu Pediat Hosp, Dept Pediat Cardiol & Cardiac Surg Heart & Lung T, Heart Failure Heart Transplant Mech Circulatory S, Heart Failure Clin,IRCCS, I-00165 Rome, Italy

[2] Bambino Gesu Pediat Hosp, Dept Pediat Cardiol & Cardiac Surg, Syncope Unit, Pediat Cardiol & Cardiac Arrhythmias,IRCCS, I-00165 Rome, Italy

[3] Bambino Gesu Pediat Hosp, IRCCS, Genet & Rare Dis Res Area, Neuromuscolar Dis, I-00165 Rome, Italy

[4] Fdn Policlin Univ A, Dept Cardiovasc & Thorac Sci, Gemelli IRCCS, I-20097 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 10期

关键词：

duchenne muscular distrophy; dilated cardiomyopathy; heart failure; VENTRICULAR ASSIST DEVICE; CONVERTING ENZYME-INHIBITORS; BECKER MUSCULAR-DYSTROPHY; MECHANICAL CIRCULATORY SUPPORT; HEART-FAILURE; DESTINATION THERAPY; ECHOCARDIOGRAPHIC MEASURES; SYSTOLIC DYSFUNCTION; MYOCARDIAL FIBROSIS; PEDIATRIC-PATIENTS;

D O I：

10.3390/jcm9103186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Duchenne muscular dystrophy (DMD) cardiomyopathy (DCM) is characterized by a hypokinetic, dilated phenotype progressively increasing with age. Regular cardiac care is crucial in DMD care. Early recognition and prophylactic use of angiotensin converting enzyme inhibitors (ACEi) are the main stay therapeutic strategy to delay incidence of DMD-DCM. Pharmacological treatment to improve symptoms and left ventricle (LV) systolic function, have been widely implemented in the past years. Because of lack of DMD specific drugs, actual indications for established DCM include current treatment for heart failure (HF). This review focuses on current HF strategies to identify, characterize, and treat DMD-DCM.

引用

页码：1 / 18

页数：18

共 113 条

[41] Patterns of late gadolinium enhancement in Duchenne muscular dystrophy carriers [J].

Giglio, Vincenzo ;

Puddu, Paolo Emilio ;

Camastra, Giovanni ;

Sbarbati, Stefano ;

Della Sala, Sabino Walter ;

Ferlini, Alessandra ;

Gualandi, Francesca ;

Ricci, Enzo ;

Sciarra, Federico ;

Ansalone, Gerardo ;

Di Gennaro, Marco .

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2014, 16

[42]

Hammerer-Lercher A, 2001, CLIN CHEM, V47, P451

[43] DYSTROPHIN - THE PROTEIN PRODUCT OF THE DUCHENNE MUSCULAR-DYSTROPHY LOCUS [J].

HOFFMAN, EP ;

BROWN, RH ;

KUNKEL, LM .

CELL, 1987, 51 (06) :919-928

[44] Phase 1 trial of vamorolone, a first-in-class steroid, shows improvements in side effects via biomarkers bridged to clinical outcomes [J].

Hoffman, Eric P. ;

Riddle, Valerie ;

Siegler, Maxime A. ;

Dickerson, Daniel ;

Backonja, Miroslav ;

Kramer, William G. ;

Nagaraju, Kanneboyina ;

Gordish-Dressman, Heather ;

Damsker, Jesse M. ;

McCall, John M. .

STEROIDS, 2018, 134 :43-52

[45] Implantation of a left ventricular assist device as a destination therapy in Duchenne muscular dystrophy patients with end stage cardiac failure: Management and lessons learned [J].

Iodice, Francesca ;

Testa, Giuseppina ;

Averardi, Marco ;

Brancaccio, Gianluca ;

Amodeo, Antonio ;

Cogo, Paola .

NEUROMUSCULAR DISORDERS, 2015, 25 (01) :19-23

[46] Female dystrophinopathy: Review of current literature [J].

Ishizaki, Masatoshi ;

Kobayashi, Michio ;

Adachi, Katsuhito ;

Matsumura, Tsuyoshi ;

Kimur, En .

NEUROMUSCULAR DISORDERS, 2018, 28 (07) :572-581

[47] Genetic predictors and remodeling of dilated cardiomyopathy in muscular dystrophy [J].

Jefferies, JL ;

Eidem, BW ;

Belmont, JW ;

Craigen, WJ ;

Ware, SM ;

Fernbach, SD ;

Neish, SR ;

Smith, EO ;

Towbin, JA .

CIRCULATION, 2005, 112 (18) :2799-2804

[48] Beta-blocker therapy for cardiac dysfunction in patients with muscular dystrophy [J].

Kajimoto, Hidemi ;

Ishigaki, Keiko ;

Okumura, Kenichi ;

Tomimatsu, Hirofumi ;

Nakazawa, Makoto ;

Saito, Kayoko ;

Osawa, Makiko ;

Nakanishi, Toshio .

CIRCULATION JOURNAL, 2006, 70 (08) :991-994

[49] Cardiac involvement of female carrier of Duchenne muscular dystrophy [J].

Kamakura, K .

INTERNAL MEDICINE, 2000, 39 (01) :2-3

[50] Dystrophin-Deficient Cardiomyopathy [J].

Kamdar, Forum ;

Garry, Daniel J. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (21) :2533-2546

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