Distant metastasis in triple-negative breast cancer

被引：95

作者：

Tseng, L. M. ^{[1
,2
]}

Hsu, N. C. ^{[3
]}

Chen, S. C. ^{[4
]}

Lu, Y. S. ^{[5
,6
]}

Lin, C. H. ^{[5
]}

Chang, D. Y. ^{[5
]}

Li, H. ^{[7
]}

Lin, Y. C. ^{[8
,9
]}

Chang, H. K. ^{[8
,9
]}

Chao, T. C. ^{[10
]}

Ouyang, F. ^{[11
,13
]}

Hou, M. F. ^{[11
,12
,13
,14
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Surg, Taipei, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung, Taiwan

[4] Chang Gung Mem Hosp, Dept Surg, Tao Yuan, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan

[6] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan

[7] DUKE NUS Grad Med Sch, Singapore, Singapore

[8] Chang Gung Mem Hosp, Div Med Oncol, Dept Med, Taipei 10591, Taiwan

[9] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan

[10] Taipei Vet Gen Hosp, Div Hematol & Oncol, Dept Internal Med, Taipei, Taiwan

[11] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan

[12] Kaohsiung Med Univ, Natl Sun Yat Sen Univ, Joint Res Ctr, Kaohsiung, Taiwan

[13] Kaohsiung Med Univ Hosp, Div Gen & Gastroenterol Surg, Dept Surg, Kaohsiung, Taiwan

[14] Kaohsiung Municipal Tatung Hosp, Kaohsiung, Taiwan

来源：

NEOPLASMA | 2013年 / 60卷 / 03期

关键词：

triple-negative breast cancer; metastasis; survival; BRAIN METASTASES; SURVIVAL; SUBTYPES; CARCINOMAS; EXPRESSION; RECURRENCE; PATTERNS; ESTROGEN; SPREAD;

D O I：

10.4149/neo_2013_038

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triple-negative breast cancer (TNBC) relapses more frequently than hormone receptor-positive subtypes and is often associated with poor outcomes. This retrospective study reviewed the pattern of distant metastasis with regard to survival in patients with TNBC. A total of 205 TNBC patients were analyzed. TNBC patients with lung metastases had the longest median post-metastatic OS (with 95% confidence interval) of 16.6 (10.3-22.9) months, followed by the bone, 16.3(11.7-20.8) months, the liver, 8.9(3.5-14.4) months, the pleura, 7.5 (2.8-12.3) months, and the brain, 4.3 (0.6-8.0) months. Kaplan-Meier plots indicated that TNBC patients with metastatic spread to brain, liver, and pleural had poorer post-metastatic OS rate than patients with lung metastases (p = 0.001, 0.004, and 0.029, respectively). Moreover, brain and liver metastases correlated significantly with poorer post-metastatic OS as compared to bone metastasis (p = 0.004 and 0.011, respectively). Route of first metastasis correlated significantly with survival of TNBC patients with brain metastases being the poorest survival indicator, followed by metastases to liver, pleura, bone, and lung.

引用

页码：290 / 294

页数：5

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