Antioxidant, a pro-oxidant and cytotoxic effects of Achyrocline satureioides extracts

被引：66
|
作者：
Polydoro, M
de Souza, KCB
Andrades, ME
Da Silva, EG
Bonatto, F
Heydrich, J
Dal-Pizzol, F
Schapoval, EES
Bassani, VL
Moreira, JCF
机构：
[1] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Lab Extresse Oxidat, BR-90035003 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande Sul, Fac Farm, Porgrama Posgrad Ciencias Farmaceut, BR-90035003 Porto Alegre, RS, Brazil
[3] Univ Extremo Sul Catarinense, Dept Med, Criciuma, SC, Brazil
来源：
LIFE SCIENCES | 2004年 / 74卷 / 23期
关键词：
flavonoids; Achyrocline satureioides; TRAP; antioxidant potential; ROS;
D O I：
10.1016/j.lfs.2003.09.073
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which increased in the presence of human plasma. Characterization of the content of flavonoids in each extract showed that the FDP80 (ethanol 80%) and FFr (enriched flavonoid fraction) extracts contained a higher content of flavonoids. Cytotoxicity of the extracts as determined in Sertoli cell culture showed that FDP80 and FFr were highly toxic at most concentrations tested. The extracts induced a significant increase in lipid peroxidation levels in Sertoli cells. These results suggest that medicinal herb extracts that contain higher flavonoid concentrations and shows higher antioxidant protection in vitro might not always produce the greatest benefit. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：2815 / 2826
页数：12
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