Immune dysfunction and neuroinflammation in autism spectrum disorder

被引：132

作者：

Bjorklund, Geir ^{[1
]}

Saad, Khaled ^{[2
]}

Chirumbolo, Salvatore ^{[3
]}

Kern, Janet K. ^{[4
]}

Geier, David A. ^{[4
]}

Geier, Mark R. ^{[4
]}

Urbina, Mauricio A. ^{[5
]}

机构：

[1] Council Nutr & Environm Med, Mo I Rana, Norway

[2] Assiut Univ, Fac Med, Dept Pediat, Assiut, Egypt

[3] Univ Verona, Dept Neurol & Movement Sci, Verona, Italy

[4] Inst Chron Illnesses Inc, Silver Spring, MD USA

[5] Univ Concepcion, Fac Ciencias Nat & Oceanog, Dept Zool, Concepcion, Chile

来源：

ACTA NEUROBIOLOGIAE EXPERIMENTALIS | 2016年 / 76卷 / 04期

关键词：

autism; cytokines; innate immunity; neuroinflammation; ELEVATED SERUM-LEVELS; BRAIN-SPECIFIC AUTOANTIBODIES; PERIPHERAL-BLOOD; EARLY MARKERS; VITAMIN-D; T-CELLS; GASTROINTESTINAL SYMPTOMS; NEUROIMMUNE ALTERATIONS; ANTIBRAIN ANTIBODIES; PREFRONTAL CORTEX;

D O I：

10.21307/ane-2017-025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder with a complex pathogenesis. Many studies over the last four decades have recognized altered immune responses among individuals diagnosed with ASD. The purpose of this critical and comprehensive review is to examine the hypothesis that immune dysfunction is frequently present in those with ASD. It was found that often individuals diagnosed with ASD have alterations in immune cells such as T cells, B cells, monocytes, natural killer cells, and dendritic cells. Also, many individuals diagnosed with ASD have alterations in immunoglobulins and increased autoantibodies. Finally, a significant portion of individuals diagnosed with ASD have elevated peripheral cytokines and chemokines and associated neuroinflammation. In conclusion, immune dysregulation and inflammation are important components in the diagnosis and treatment of ASD.

引用

页码：257 / 268

页数：12

共 150 条

[41] Differential monocyte responses to TLR ligands in children with autism spectrum disorders [J].