Tumor-associated macrophages in thoracic malignancies

被引：58
作者：
Lievense, L. A. [1 ]
Bezemer, K. [1 ]
Aerts, J. G. J. V. [1 ,2 ]
Hegmans, J. P. J. J. [1 ]
机构：
[1] Erasmus MC, Dept Pulm Med, NL-3000 CA Rotterdam, Netherlands
[2] Amphia Hosp, Dept Pulm Med, Breda, Netherlands
来源：
LUNG CANCER | 2013年 / 80卷 / 03期
关键词：
Immunotherapy; Immuno-oncology; Lung cancer; Mesothelioma; Tumor microenvironment; Personalized medicine; CELL-LUNG-CANCER; REGULATORY T-CELLS; HUMAN PLEURAL MESOTHELIOMA; BREAST-CANCER; IMMUNE SURVEILLANCE; GROWTH-FACTORS; SURVIVAL-TIME; KAPPA-B; EXPRESSION; INFILTRATION;
D O I：
10.1016/j.lungcan.2013.02.017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor-associated macrophages (TAMs) can be abundantly present in numerous cancer types. Under influence of various stimuli in the tumor microenvironment TAMs develop into a tumor-inhibitory (M1) or tumor-promoting (M2) phenotype. Recently, the role of TAMs in tumor biology and their prognostic value in cancer has become a major topic of interest. In this review we will discuss the importance of TAMs in the pathogenesis and clinical outcome of lung cancer and mesothelioma patients. In addition, the potential of TAMs as therapeutic targets will be discussed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：256 / 262
页数：7
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