A polymeric composite carrier for oral delivery of peptide drugs: Bilaminated hydrogel film loaded with nanoparticles

被引：31

作者：

He, Chunbai ^{[1
]}

Cui, Fuying ^{[1
]}

Yin, Lichen ^{[1
]}

Qian, Feng ^{[1
]}

Tang, Cui ^{[1
]}

Yin, Chunhua ^{[1
]}

机构：

[1] Fudan Univ, Dept Pharmaceut Sci, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2009年 / 45卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Nanoparticles; Bilaminated films; pH-sensitivity; Mucoadhesive force; Calcein; MUCOADHESIVE POLYMERS; CONTROLLED-RELEASE; INSULIN DELIVERY; PROTEIN DRUGS; ALGINATE; CHITOSAN; CHALLENGES; NETWORKS; DEVICES; SYSTEMS;

D O I：

10.1016/j.eurpolymj.2008.11.004

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A smart polymeric composite carrier consisting of carboxylated chitosan grafted nanoparticles (CCGN) and bilaminated films with one alginate-Ca2+ mucoadhesive layer and one hydrophobic backing layer was developed as a novel carrier for peptide. Calcein, hydrophilic and hydrolytic degradative, was entrapped into CCGN as a model peptide and its release behavior was investigated. Morphology study showed a uniform distribution of CCGN in the homogeneous and porous hydrogel. CCGN was characterized by Fourier transform infrared spectroscopy (FTIR). X-ray diffraction (XRD), particle size measurement, and potential measurement. The composite carrier was characterized by differential scanning calorimetry (DSC), scanning electron microscope (SEM) and fluorescence microscopy. The carrier exhibited high mucoadhesive force and pH-sensitivity, in that release of the nanoparticles and the model peptide calcein were both restricted in acidic environment while a fast and complete release was achieved in neutral medium. Therefore, this novel carrier Would be a promising candidate for hydrophilic peptide drugs via oral administration. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：368 / 376

页数：9

共 33 条

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