The progress of research into pseudophosphatases

被引：0

作者：

Liu, Deqiang ^{[1
]}

Zhang, Yiming ^{[1
]}

Fang, Hui ^{[1
]}

Yuan, Jinxiang ^{[1
,2
]}

Ji, Lizhen ^{[1
]}

机构：

[1] Shandong Normal Univ, Coll Life Sci, Jinan, Peoples R China

[2] Jining Med Univ, Collaborat Innovat Ctr, Jining, Peoples R China

来源：

FRONTIERS IN PUBLIC HEALTH | 2022年 / 10卷

关键词：

pseudophosphatase; protein tyrosine phosphatases (PTPs); myotubularin phosphatases (MTMs); phosphatase and tensin homologues (PTENs); dual specificity phosphatases (DUSPs); PHOSPHATASE; PROTEIN; MYOTUBULARIN; STYX; PTP; DOMAIN; IDENTIFICATION; PREDISPOSES; SPECIFICITY; METASTASIS;

D O I：

10.3389/fpubh.2022.965631

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Pseudophosphatases are a class of phosphatases that mutate at the catalytically active site. They play important parts in many life processes and disorders, e.g., cell apoptosis, stress reaction, tumorigenesis, axon differentiation, Charcot-Marie-Tooth, and metabolic dysfunction. The present review considers the structures and action types of pseudophosphatases in four families, protein tyrosine phosphatases (PTPs), myotube protein phosphatases (MTMs), phosphatases and tensin homologues (PTENs) and dual specificity phosphatases (DUSPs), as well as their mechanisms in signaling and disease. We aimed to provide reference material for the research and treatment of related diseases.

引用

页数：8

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