Involvement of cancer-activating genes on chromosomes 7 and 8 in esophageal (Barrett's) and gastric cardia adenocarcinoma

被引:0
作者
Vissers, KJ
Riegman, PHJ
Alers, JC
Tilanus, HW
Van Dekken, H
机构
[1] Erasmus Univ, Dept Pathol, Josephine Nefkens Inst, NL-3000 DR Rotterdam, Netherlands
[2] Erasmus Univ, Dept Surg, NL-3000 DR Rotterdam, Netherlands
关键词
Barrett's esophagus; gastric cardia; adenocarcinoma; comparative genomic hybridization; immunohistochemistry; oncogenes;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The incidence of adenocarcinomas of the distal esophagus (Barrett's esophagus) and proximal stomach (gastric cardia) has increased rapidly over the past decades. In contrast to this dramatic increase, genetic knowledge is sparse. Materials and Methods: We investigated genomic amplification on chromosomes 7 and 8 by comparative genomic hybridization (CGH) and protein expression of relevant oncogenes (EGFR, HGF, MET, CTSB, MYC by immunohistochemistry (IHC) in 22 esophageal and 22 gastric cardia carcinomas. Results: The CGH and IHC patterns were very similar for the two cancer locations. IHC showed positive immunostaining in 93% of the adenocarcinomas for at least one of the investigated genes, whereas CGH disclosed genomic gains on chromosome 7 and/or 8 in 80%. Conclusion: Cancer-activating genes on chromosomes 7 and 8 are frequently involved in gastro-esophageal junction adenocarcinomas. Moreover, the similarities in chromosomal changes and protein expression patterns strongly suggest that esophageal and gastric cardia adenocarcinomas have a shared etiology. This is in agreement with studies addressing gastro-esophageal reflux disease and intestinal metaplasia at these locations.
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收藏
页码:3813 / 3820
页数:8
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