Organometallic gold(I) and gold(III) complexes for lung cancer treatment

被引：12

作者：

Zhang, Juzheng ^{[1
]}

Li, Yanping ^{[2
]}

Fang, Ronghao ^{[1
]}

Wei, Wei ^{[1
]}

Wang, Yong ^{[1
]}

Jin, Jiamin ^{[1
]}

Yang, Feng ^{[3
]}

Chen, Jian ^{[1
]}

机构：

[1] Guilin Med Univ, Guangxi Key Lab Tumor Immunol & Microenvironm Regu, Guilin, Peoples R China

[2] Guilin Med Univ, Sch Publ Hlth, Guilin, Peoples R China

[3] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

关键词：

Gold(I) complexes; gold(III) complexes; anticancer; lung cancer; A549; POTENTIAL ANTICANCER ACTIVITY; AURANOFIN; THIOREDOXIN; PHOSPHINE; CYTOTOXICITY; GEFITINIB; LIGANDS; AGENT; INHIBITORS; APOPTOSIS;

D O I：

10.3389/fphar.2022.979951

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Metal compounds, especially gold complexes, have recently gained increasing attention as possible lung cancer therapeutics. Some gold complexes display not only excellent activity in cisplatin-sensitive lung cancer but also in cisplatin-resistant lung cancer, revealing promising prospects in the development of novel treatments for lung cancer. This review summarizes examples of anticancer gold(I) and gold (III) complexes for lung cancer treatment, including mechanisms of action and approaches adopted to improve their efficiency. Several excellent examples of gold complexes against lung cancer are highlighted.

引用

页数：19

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