Self-assembled tannic acid complexes for pH-responsive delivery of antibiotics: Role of drug-carrier interactions

被引:42
作者
Abouelmagd, Sara A. [1 ,5 ]
Abd Ellah, Noura H. [1 ,6 ]
Amen, Omar [2 ]
Abdelmoez, Alshaimaa [3 ]
Mohamed, Noha G. [4 ]
机构
[1] Assiut Univ, Fac Pharm, Dept Pharmaceut, Assiut, Egypt
[2] Assiut Univ, Fac Vet Med, Dept Poultry Dis, Assiut, Egypt
[3] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut, Egypt
[4] Assiut Univ, Fac Pharm, Student Res Unit, Assiut, Egypt
[5] Assiut Univ, Drug Res Ctr, Assiut, Egypt
[6] Univ Cincinnati, James L Winkle Coll Pharm, Div Pharmaceut Sci, Cincinnati, OH USA
关键词
Tannic acid; Electrostatic complexes; pH-responsive; Drug-carrier interactions; Antibiotics; Triggered release; HYDROGEN-BONDED MULTILAYERS; CHITOSAN; RELEASE; NANOTECHNOLOGY; NANOPARTICLES; STABILITY; POLYMER; FILMS;
D O I
10.1016/j.ijpharm.2019.03.009
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Self-assembled particles, based on non-covalent interactions, are attractive drug carriers with a relatively simple structure and easy preparation. Tannic acid (TA) is an anionic polyphenolic compound with a wide range of molecular interactions and diverse applications in drug delivery research. Here, we propose the use of TA complexes with cationic antibiotics as a new pH-responsive drug carrier of high drug loading and optimal stability. TA complexes were prepared with three water-soluble antibiotics; colistin sulfate (COL), gentamicin sulfate (GEN) and gatifloxacin (GAT). Complexes' size ranged from several-hundred nanometers to few microns. For selected particles, drug loading ranged from 30 to 36%. Importantly, we demonstrate the impact of drugcarrier interactions, studied via infrared spectroscopy and molecular modeling, on final complex stability and performance; the complexes resisted dissociation in presence of serum at physiological pH to variable degrees and showed different drug release profiles. However, all complexes dissociated upon medium acidification, releasing their drug payload and demonstrating expected antibacterial effect. These results demonstrate that TA/antibiotic self-assembled complexes represent an excellent carrier for pH-sensitive delivery of water-soluble drugs. In addition to system's simplicity and low cost, complexes were easily prepared with high drug loading and desirable pH-dependent association/dissociation profile.
引用
收藏
页码:76 / 85
页数:10
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