Non-Pulmonary Immune Functions of Surfactant Proteins A and D

被引：35

作者：

Ujma, Sylvia ^{[1
,2
,3
]}

Horsnell, William G. C. ^{[2
,4
]}

Katz, Arieh A. ^{[1
,2
,3
]}

Clark, Howard W. ^{[5
]}

Schafer, Georgia ^{[1
,2
,3
]}

机构：

[1] Univ Cape Town, Fac Hlth Sci, Div Med Biochem & Struct Biol, UCT Receptor Biol Res Unit,Dept Integrat Biomed S, Cape Town, South Africa

[2] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Cape Town, South Africa

[3] Univ Cape Town, Fac Hlth Sci, SAMRC Gynecol Canc Res Ctr, Cape Town, South Africa

[4] Univ Cape Town, Fac Hlth Sci, Div Immunol, Dept Pathol, Cape Town, South Africa

[5] Univ Southampton, Dept Child Hlth, Div Clin & Expt Sci, Child Hlth, Southampton, Hants, England

来源：

JOURNAL OF INNATE IMMUNITY | 2017年 / 9卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Surfactant protein A; Surfactant protein D; Female reproductive tract; Urinary tract; Gastrointestinal tract; UROPATHOGENIC ESCHERICHIA-COLI; RESPIRATORY SYNCYTIAL VIRUS; FEMALE REPRODUCTIVE-TRACT; CORNEAL EPITHELIAL-CELLS; SMOOTH-MUSCLE-CELLS; SP-A; URINARY-TRACT; MYCOBACTERIUM-TUBERCULOSIS; PSEUDOMONAS-AERUGINOSA; CHRONIC RHINOSINUSITIS;

D O I：

10.1159/000451026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, the eye, ear, nasal compartment, central nervous system, the coronary artery and the skin. The functions of SP-A and SP-D at these sites are a relatively underinvestigated area, but it is emerging that both SP-A and SP-D contribute significantly to the regulation of inflammation and protection from infection at these sites. This review presents our current understanding of the roles of SP-A and SP-D in non-pulmonary sites. (C) 2016 S. Karger AG, Basel

引用

页码：3 / 11

页数：9

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