The 677C>T Mutation of the MTHFR Gene Increases the Risk of Venous Thromboembolism in Koreans and a Meta-Analysis From Asian Population

被引：15
作者：
Jang, Moon Ju [1 ]
Jeon, Young Joo [2 ]
Choi, Won-il [3 ]
Choi, Yi Seul [2 ]
Kim, Su Yeoun [2 ]
Chong, So Young [1 ]
Oh, Doyeun [1 ]
Kim, Nam Keun [2 ]
机构：
[1] CHA Univ, Dept Internal Med, Sch Med, Songnam 463712, South Korea
[2] CHA Univ, Inst Clin Res, CHA Bundang Med Ctr, Sch Med, Songnam 463712, South Korea
[3] Keymyung Univ, Dept Internal Med, Coll Med, Taegu, South Korea
来源：
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2013年 / 19卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
methylenetetrahydrofolate reductase; 677C > T; 1298A > C; venous thromboembolism; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; DEEP-VEIN THROMBOSIS; COMMON MUTATION; THROMBOGENIC AGENT; VASCULAR-DISEASE; FACTOR-V; HOMOCYSTEINE; C677T; POLYMORPHISMS; HYPERHOMOCYSTEINEMIA;
D O I：
10.1177/1076029612436677
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The frequency of methylenetetrahydrofolate reductase (MTHFR) mutations varies between racial and ethnic groups, and there are also conflicting data regarding MTHFR gene mutations in Asian patients with venous thromboembolism (VTE). The aim of this study was to examine the association between common MTHFR gene mutations (677C>T and 1298A>C) and risk of VTE in Koreans. This study was a retrospective case-control study. We enrolled 203 patients with VTE and 403 controls. For the 677C>T polymorphism, there was no difference in the frequency of the CT genotype and TT genotype between the patients with VTE and the controls. However, in the recessive analysis (CC + CT vs TT), the frequency of the TT genotype was significantly higher in VTE than in controls (odds ratio = 1.700; 95% confidence interval = 1.108-2.607, P = .015). In conclusion, the TT genotype of MTHFR 677C>T increases the risk of VTE in Koreans. This finding was supported by meta-analysis of previous Asian studies.
引用
收藏
页码：309 / 314
页数：6
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