Comparison of the immune activation capacities of fucoidan and laminarin extracted from Laminaria japonica

被引:39
作者
An, Eun-Koung [1 ,2 ]
Hwang, Juyoung [1 ,2 ]
Kim, So-Jung [1 ,2 ]
Park, Hae-Bin [1 ]
Zhang, Wei [3 ]
Ryu, Ja-Hyoung [4 ]
You, SangGuan [5 ]
Jin, Jun-O [1 ,2 ]
机构
[1] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, South Korea
[2] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea
[3] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
[4] Ulsan Natl Inst Sci & Technol UNIST, Dept Chem, Ulsan 44919, South Korea
[5] Gangneung Wonju Natl Univ, Dept Marine Food Sci & Technol, Gangwon, South Korea
基金
新加坡国家研究基金会;
关键词
Laminaria japonica; Fucoidan; Laminarin; Immune activation; Anticancer; INNATE IMMUNITY; POLYSACCHARIDES; CELLS;
D O I
10.1016/j.ijbiomac.2022.03.122
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Laminaria japonica is a brown alga and is composed primarily of polysaccharides. Fucoidan and laminarin are the major polysaccharides of L. japonica and exhibit biological activities, including immune modulation and anticoagulant and antioxidant effects in animals and humans. In this study, we evaluated the ability of fucoidan and laminarin from L. japonica to induce immune cell activation and anti-cancer immunity, which has not yet been studied. The injection of fucoidan to mice promoted the upregulation of major histocompatibility complex and surface activation molecules in splenic dendritic cell subsets, whereas laminarin showed a weaker immune activation ability. In addition, fucoidan treatment elicited inflammatory cytokine production; however, laminarin did not induce the production of these cytokines. Regarding cytotoxic cell activities, fucoidan induced the activation of lymphocytes, including natural killer and T cells, whereas laminarin did not induce cell activation. Finally, fucoidan enhanced the anticancer efficacy of anti-programmed Death-Ligand 1 (PD-L1) antibody against Lewis lung carcinoma, whereas laminarin did not promote the cancer inhibition effect of anti-PD-L1 antibody. Thus, these data suggest that fucoidan from L. japonica can be used as an immune stimulatory molecule to enhance the anticancer activities of immune checkpoint inhibitors.
引用
收藏
页码:230 / 242
页数:13
相关论文
共 38 条
[1]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[2]   Scavenger receptors: role in innate immunity and microbial pathogenesis [J].
Areschoug, Thomas ;
Gordon, Siamon .
CELLULAR MICROBIOLOGY, 2009, 11 (08) :1160-1169
[3]   Innate immunity: an overview [J].
Beutler, B .
MOLECULAR IMMUNOLOGY, 2004, 40 (12) :845-859
[4]   Adaptive immunity [J].
Bonilla, Francisco A. ;
Oettgen, Hans C. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (02) :S33-S40
[5]   Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy [J].
Chester, Cariad ;
Fritsch, Katherine ;
Kohrt, Holbrook E. .
FRONTIERS IN IMMUNOLOGY, 2015, 6
[6]   Polysaccharides from Laminaria japonica: Structural characteristics and antioxidant activity [J].
Cui, Chun ;
Lu, Jianghong ;
Sun-Waterhouse, Dongxiao ;
Mu, Lixia ;
Sun, Weizheng ;
Zhao, Mouming ;
Zhao, Haifeng .
LWT-FOOD SCIENCE AND TECHNOLOGY, 2016, 73 :602-608
[7]   Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides [J].
Dobrincic, Ana ;
Balbino, Sandra ;
Zoric, Zoran ;
Pedisic, Sandra ;
Kovacevic, Danijela Bursac ;
Garofulic, Ivona Elez ;
Dragovic-Uzelac, Verica .
MARINE DRUGS, 2020, 18 (03)
[8]   Activation and Regulation of B Cell Responses by invariant Natural Killer T Cells [J].
Doherty, Derek G. ;
Melo, Ashanty M. ;
Moreno-Olivera, Ana ;
Solomos, Andreas C. .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[9]   Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment [J].
Fu, Chunmei ;
Jiang, Aimin .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[10]   Cross-Talk Between Antigen Presenting Cells and T Cells Impacts Intestinal Homeostasis, Bacterial Infections, and Tumorigenesis [J].
Gaudino, Stephen J. ;
Kumar, Pawan .
FRONTIERS IN IMMUNOLOGY, 2019, 10