Evidence for loss of heterozygosity (LOH) at chromosomes 9p and 17p in oral granular cell tumors: a pilot study

被引：11

作者：

Gomes, Carolina Cavalieri ^{[1
]}

Fonseca-Silva, Thiago ^{[2
]}

Gomez, Ricardo Santiago ^{[2
]}

机构：

[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pathol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY | 2013年 / 115卷 / 02期

关键词：

SUPPRESSOR GENES; ALLELIC LOSS; PTCH GENE; CARCINOMA; P53; EXPRESSION; PROLIFERATION; AMELOBLASTOMA; APOPTOSIS; CANCER;

D O I：

10.1016/j.oooo.2012.11.011

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. The objective of this study was to assess loss of heterozygosity (LOH) in tumor suppressor gene loci in oral granular cell tumors (GCTs). Study Design. We assessed LOH in 8 samples of oral GCT using polymorphic microsatellite markers at chromosome regions 3p, 9p, 11q, and 17p, flanking areas close to tumor suppressor genes. We further performed immunohistochemistry to detect the p53 and Ki-67 proteins and associated these expressions with the molecular results. Results. Five samples showed LOH in 3 markers at chromosomes 9p and 17p (markers P53, AFM238WF2 and D9S162) with fraction of allelic loss of 42.8% for each of these markers. No LOH was identified in any other chromosome. LOH was not associated with the immunohistochemical expression of p53 and Ki-67. Conclusions. The present study shows LOH at chromosomes 9p and 17p in oral GCTs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:249-253)

引用

页码：249 / 253

页数：5

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