Differential expression of viral Bcl-2 encoded by Kaposi's sarcoma-associated herpesvirus and human Bcl-2 in primary effusion lymphoma cells and Kaposi's sarcoma lesions

被引：20
作者：
Widmer, I
Wernli, M
Bachmann, F
Gudat, F
Cathomas, G
Erb, P
机构：
[1] Univ Basel, Inst Med Microbiol, CH-4003 Basel, Switzerland
[2] Univ Basel, Inst Pathol, CH-4003 Basel, Switzerland
[3] Inst Pathol, CH-4410 Liestal, Switzerland
来源：
JOURNAL OF VIROLOGY | 2002年 / 76卷 / 05期
关键词：
D O I：
10.1128/JVI.76.5.2551-2556.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Expression of human herpesvirus 8 viral Bcl-2 protein was demonstrated in spindle cells of late-stage Kaposi's sarcoma lesions but not in primary effusion lymphoma cell lines. In contrast, strong expression of human Bcl-2 was found in stimulated primary effusion lymphoma cells, whereas in Kaposi's sarcoma lesions preferential mononuclear cells, and to a lesser extent spindle cells, stained positive.
引用
收藏
页码：2551 / 2556
页数：6
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