NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

被引：221

作者：

Carrega, Paolo ^{[1
]}

Loiacono, Fabrizio ^{[1
]}

Di Carlo, Emma ^{[2
,3
]}

Scaramuccia, Angelo ^{[4
]}

Mora, Marco ^{[4
]}

Conte, Romana ^{[4
]}

Benelli, Roberto ^{[4
]}

Spaggiari, Grazia Maria ^{[5
]}

Cantoni, Claudia ^{[1
,5
,6
]}

Campana, Stefania ^{[7
]}

Bonaccorsi, Irene ^{[7
]}

Morandi, Barbara ^{[5
]}

Truini, Mauro ^{[4
]}

Mingari, Maria Cristina ^{[4
,5
,6
]}

Moretta, Lorenzo ^{[8
]}

Ferlazzo, Guido ^{[7
,9
]}

机构：

[1] Ist Giannina Gaslini, I-16148 Genoa, Italy

[2] Univ G dAnnunzio, Dept Med & Sci Aging, I-66013 Chieti, Italy

[3] Fdn Univ G dAnnunzio, Ctr Sci Invecchiamento, I-66013 Chieti, Italy

[4] Azienda Osped Univ San Martino, IST Ist Nazl Ric Cancro, Ist Ricovero & Cura Carattere Sci, I-16132 Genoa, Italy

[5] Univ Genoa, Dept Expt Med DIMES, I-16132 Genoa, Italy

[6] Univ Genoa, Ctr Eccellenza Ric Biomed CEBR, Ctr Excellence Biomed Res, I-16132 Genoa, Italy

[7] Univ Messina, Dept Human Pathol, Lab Immunol & Biotherapy, I-98125 Messina, Italy

[8] IRCCS Bambino Gesu Childrens Hosp, Dept Immunol, Rome, Italy

[9] Azienda Osped Univ Policlin Gaetano Martino, Cell Therapy Program, I-98125 Messina, Italy

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

关键词：

NATURAL-KILLER-CELLS; ROR-GAMMA-T; TISSUE-INDUCER CELLS; HUMAN NK CELLS; CYTOTOXICITY RECEPTORS; IMMUNITY; NKP30; DIFFERENTIATION; IDENTIFICATION; ORGANOGENESIS;

D O I：

10.1038/ncomms9280

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tertiary lymphoid structures (TLSs) are a common finding in non-small cell lung cancer (NSCLC) and are predictors of favourable clinical outcome. Here we show that NCR+ innate lymphoid cell (ILC)-3 are present in the lymphoid infiltrate of human NSCLC and are mainly localized at the edge of tumour-associated TLSs. This intra-tumoral lymphocyte subset is endowed with lymphoid tissue-inducing properties and, on activation, produces IL-22, TNF-alpha, IL-8 and IL-2, and activates endothelial cells. Tumour NCR(+)ILC3 may interact with both lung tumour cells and tumour-associated fibroblasts, resulting in the release of cytokines primarily on engagement of the NKp44-activating receptor. In patients, NCR(+)ILC3 are present in significantly higher amounts in stage I/II NSCLC than in more advanced tumour stages and their presence correlate with the density of intratumoral TLSs. Our results indicate that NCR(+)ILC3 accumulate in human NSCLC tissue and might contribute to the formation of protective tumour-associated TLSs.

引用

页数：13

共 60 条

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