Next-generation in vivo optical imaging with short-wave infrared quantum dots

被引：539

作者：

Bruns, Oliver T. ^{[1
]}

Bischof, Thomas S. ^{[1
]}

Harris, Daniel K. ^{[1
,2
]}

Franke, Daniel ^{[1
]}

Shi, Yanxiang ^{[3
]}

Riedemann, Lars ^{[4
,5
,12
,13
,14
]}

Bartelt, Alexander ^{[6
,7
]}

Jaworski, Frank B. ^{[8
]}

Carr, Jessica A. ^{[1
]}

Rowlands, Christopher J. ^{[9
]}

Wilson, Mark W. B. ^{[1
,15
]}

Chen, Ou ^{[1
,16
]}

Wei, He ^{[1
]}

Hwang, Gyu Weon ^{[1
,2
,17
]}

Montana, Daniel M. ^{[1
,2
]}

Coropceanu, Igor ^{[1
]}

Achorn, Odin B. ^{[1
]}

Kloepper, Jonas ^{[4
,5
,18
]}

Heeren, Joerg ^{[10
]}

So, Peter T. C. ^{[9
,11
]}

Fukumura, Dai ^{[4
,5
]}

Jensen, Klavs F. ^{[3
]}

Jain, Rakesh K. ^{[4
,5
]}

Bawendi, Moungi G. ^{[1
]}

机构：

[1] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Dept Mat Sci & Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[4] Massachusetts Gen Hosp, Edwin L Steele Labs Tumor Biol, 100 Blossom St,Cox 7, Boston, MA 02114 USA

[5] Harvard Med Sch, 100 Blossom St,Cox 7, Boston, MA 02114 USA

[6] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, 665 Huntington Ave, Boston, MA 02115 USA

[7] Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr, 665 Huntington Ave, Boston, MA 02115 USA

[8] Raytheon Vision Syst, Goleta, CA 93117 USA

[9] MIT, Dept Biochem Engn, Cambridge, MA 02139 USA

[10] Univ Med Ctr Hamburg Eppendorf, Dept Biochem & Mol Cell Biol, Martini Str 52, D-20246 Hamburg, Germany

[11] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[12] Univ Heidelberg Hosp, Neurol Clin, D-69120 Heidelberg, Germany

[13] Univ Heidelberg Hosp, Natl Ctr Tumor Dis, D-69120 Heidelberg, Germany

[14] German Canc Res Ctr, German Canc Consortium, Clin Cooperat Unit Neuro Oncol, D-69120 Heidelberg, Germany

[15] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

[16] Brown Univ, Dept Chem, Providence, RI 02912 USA

[17] Korea Inst Sci & Technol, Seoul 02792, South Korea

[18] CHUV UNIL, Dept Med Interne, Ctr Hosp Univ Vaudois, Rue Bugnon 46, CH-1011 Lausanne, Switzerland

来源：

NATURE BIOMEDICAL ENGINEERING | 2017年 / 1卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

LIPOPROTEIN METABOLISM; CARBON NANOTUBES; NANOCRYSTALS; EMISSION; BRIGHT; VELOCITY; DENSITY; WINDOW; BRAIN; PROBE;

D O I：

10.1038/s41551-017-0056

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

For in vivo imaging, the short-wavelength infrared region (SWIR; 1,000-2,000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolour imaging and fast acquisition speed afforded by the SWIR quantum dots, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.

引用

页数：11

共 48 条

[1]

ADRIAN RJ, 1991, ANNU REV FLUID MECH, V23, P261, DOI 10.1146/annurev.fluid.23.1.261

[2] Twenty years of particle image velocimetry [J].

Adrian, RJ .

EXPERIMENTS IN FLUIDS, 2005, 39 (02) :159-169

[3] Synthesis of InAs/CdSe/ZnSe core/shell1/shell2 structures with bright and stable near-infrared fluorescence [J].

Aharoni, A ;

Mokari, T ;

Popov, I ;

Banin, U .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (01) :257-264

[4] Carbon nanotubes as in vivo bacterial probes [J].

Bardhan, Neelkanth M. ;

Ghosh, Debadyuti ;

Belcher, Angela M. .

NATURE COMMUNICATIONS, 2014, 5

[5] Brown adipose tissue activity controls triglyceride clearance [J].

Bartelt, Alexander ;

Bruns, Oliver T. ;

Reimer, Rudolph ;

Hohenberg, Heinz ;

Ittrich, Harald ;

Peldschus, Kersten ;

Kaul, Michael G. ;

Tromsdorf, Ulrich I. ;

Weller, Horst ;

Waurisch, Christian ;

Eychmueller, Alexander ;

Gordts, Philip L. S. M. ;

Rinninger, Franz ;

Bruegelmann, Karoline ;

Freund, Barbara ;

Nielsen, Peter ;

Merkel, Martin ;

Heeren, Joerg .

NATURE MEDICINE, 2011, 17 (02) :200-U93

[6]

Berndt A., 2010, MOUSE PHENOME DATABA

[7]

Bruns OT, 2009, NAT NANOTECHNOL, V4, P193, DOI [10.1038/NNANO.2008.405, 10.1038/nnano.2008.405]

[8]

Chen O, 2013, NAT MATER, V12, P445, DOI [10.1038/NMAT3539, 10.1038/nmat3539]

[9] Imaging preclinical tumour models: improving translational power [J].

de Jong, Marion ;

Essers, Jeroen ;

van Weerden, Wytske M. .

NATURE REVIEWS CANCER, 2014, 14 (07) :481-493

[10] Facile Synthesis of Highly Photoluminescent Ag2Se Quantum Dots as a New Fluorescent Probe in the Second Near-Infrared Window for in Vivo Imaging [J].

Dong, Bohua ;

Li, Chunyan ;

Chen, Guangcun ;

Zhang, Yejun ;

Zhang, Yan ;

Deng, Manjiao ;

Wang, Qiangbin .

CHEMISTRY OF MATERIALS, 2013, 25 (12) :2503-2509

← 1 2 3 4 5 →