Self-Assembled Nanoparticles: Exciting Platforms for Vaccination

被引：31
作者：
Pan, Jingdi [1 ,2 ]
Cui, Zongqiang [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Ctr Biosafety Mega Sci, Wuhan 430071, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
BIOTECHNOLOGY JOURNAL | 2020年 / 15卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ferritin; influenza virus; self-assembled nanoparticle; vaccine; virus-like particle; VIRUS-LIKE PARTICLES; INACTIVATED INFLUENZA VACCINE; PROTECTIVE IMMUNE-RESPONSE; ANTIGEN-PRESENTING CELLS; DRUG-DELIVERY; MUCOSAL IMMUNITY; EFFICIENT VACCINE; SPLIT-VIRION; PROTEIN CAGE; ADJUVANT;
D O I：
10.1002/biot.202000087
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Vaccination is successfully advanced to control several fatal diseases and improve human life expectancy. However, additional innovations are required in this field because there are no effective vaccines to prevent some infectious diseases. The shift from the attenuated or inactivated pathogens to safer but less immunogenic protein or peptide antigens has led to a search for effective antigen delivery carriers that can function as both antigen vehicles and intrinsic adjuvants. Among these carriers, self-assembled nanoparticles (SANPs) have shown great potential to be the best representative. For the nanoscale and multiple presentation of antigens, with accurate control over size, geometry, and functionality, these nanoparticles are assembled spontaneously and mimic pathogens, resulting in enhanced antigen presentation and increased cellular and humoral immunity responses. In addition, they may be applied through needle-free routes due to their adhesive ability, which gives them a great future in vaccination applications. This review provides an overview of various SANPs and their applications in prophylactic vaccines.
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页数：14
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