TOTAL SYNTHESIS OF ISOINDOLOBENZAZEPINE ALKALOIDS, LENNOXAMINE AND CHILENINE, BASED ON PALLADIUM-CATALYZED REDUCTION OF ALKENYL PHOSPHATES

被引：25
作者：
Fuwa, Haruhiko [1 ]
Sasaki, Makoto [1 ]
机构：
[1] Tohoku Univ, Grad Sch Life Sci, Lab Biostruct Chem, Aoba Ku, Sendai, Miyagi 9818555, Japan
来源：
HETEROCYCLES | 2008年 / 76卷 / 01期
关键词：
Lennoxamine; Chilenine; Isoindolobenzazepine Alkaloid; Alkenyl Phosphate; Palladium-Catalyzed Reaction;
D O I：
10.3987/COM-08-S(N)40
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of enol ethers and enecarbamates has been developed based on palladium(0)-catalyzed chemoselective reduction of alkenyl phosphates. This method has been applied successfully to the total synthesis of two isoindolobenzazepine alkaloids, lennoxamine and chilenine.
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收藏
页码：521 / 539
页数：19
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