Clinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with Undifferentiated Carcinoma of Nasopharyngeal Type

被引：33
作者：
Bortolin, MT
Pratesi, C
Dolcetti, R
Bidoli, E
Vaccher, E
Zanussi, S
Tedeschi, R
De Paoli, P
机构：
[1] IRCCS, Ctr Riferimento Oncol, Microbiol Immunol & Virol Unit, I-33081 Aviano, PN, Italy
[2] IRCCS, Ctr Riferimento Oncol, Immunovirol & Biotherapy Unit, Aviano, Italy
[3] IRCCS, Ctr Riferimento Oncol, Epidemiol Unit, Aviano, Italy
来源：
CANCER LETTERS | 2006年 / 233卷 / 02期
关键词：
Epstein-Barr virus; Undifferentiated Carcinoina of Nasopharyngeal Type; real-time PCR;
D O I：
10.1016/j.canlet.2005.03.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated EBV viremia in matched serum and peripheral blood mononuclear cells (PBMCs) from one of the largest Italian cohort of Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT) patients (N=34). By using a LMP-1 real-time PCR assay, we found that EBV DNA detection rate was 74% (median 8417 copies/ml) and 24% (median 164 copies/10(6) cells) on serum and PBMCs, respectively. Significantly higher serum EBV DNA levels were detected in patients with advanced UCNT (nodal stage N2 versus NO-1 and N3 versus NO-1, P=0.03 and 0.018; overall stage IV versus I-II, P=0.03). During the follow-up, there was also a statistically significant difference of EBV DNA viral load between patients with and without Clinical relapse (P=0.008). We concluded that serum EBV DNA reflects the biological activity of the UCNT and may be a prognostic factor also in a low-incidence region. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：247 / 254
页数：8
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