The physiological impact of microRNA gene regulation in the retina

被引：55

作者：

Sundermeier, Thomas R. ^{[1
]}

Palczewski, Krzysztof ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Pharmacol, Sch Med, Cleveland, OH 44106 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2012年 / 69卷 / 16期

基金：

美国国家卫生研究院;

关键词：

microRNA; Retina; Dicer; Photoreceptor; Argonaute; MOUSE MODEL; SMALL RNAS; POSTTRANSCRIPTIONAL REGULATION; CONGENITAL AMAUROSIS; MACULAR DEGENERATION; TARGETED DELETION; GW182; PROTEINS; BINDING-SITES; MIRNA PATHWAY; IDENTIFICATION;

D O I：

10.1007/s00018-012-0976-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are small, stable RNA molecules that post-transcriptionally regulate gene expression in plants and animals by base pairing to partially complementary sequences on target mRNAs to inhibit protein synthesis. More than 250 miRNAs are reportedly expressed in the retina, and miRNA gene regulation has been shown to affect retinal development, function, and disease. Here we highlight recent advances in understanding the functional roles of vertebrate retinal miRNAs. Details are emerging about the physiological impact of specific miRNAs in the developing and mature retina, and we discuss a group of emerging technologies for studying miRNAs, which can be employed to yield a deeper understanding of retinal miRNA gene regulation.

引用

页码：2739 / 2750

页数：12

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