Energy dissipation in slipping biological pumps

被引：37

作者：

Kjelstrup, S ^{[1
]}

Rubi, JM

Bedeaux, D

机构：

[1] Norwegian Univ Sci & Technol, Fac Nat Sci & Technol, Dept Chem, N-7491 Trondheim, Norway

[2] Univ Barcelona, Dept Fis Fonamental, Barcelona 08028, Spain

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2005年 / 7卷 / 23期

关键词：

D O I：

10.1039/b511990a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We describe active transport in slipping biological pumps, using mesoscopic nonequilibrium thermodynamics. The pump operation is characterised by its stochastic nature and energy dissipation. We show how heating as well as cooling effects can be associated with pump operation. We use as an example the well studied active transport of Ca2+ across a biological membrane by means of its ATPase, and use published data to find values for the transport coefficients of the pump under various conditions. Most of the transport coefficients of the pump, including those that relate ATP hydrolysis or synthesis to thermal effects, are estimated. This can give a quantitative description of thermogenesis. We show by calculation that all of these coupling coefficients are significant.

引用

页码：4009 / 4018

页数：10