Association of serum bisphenol A levels with incident overweight and obesity risk and the mediating effect of adiponectin

被引:6
作者
Bi, Jiao [1 ,2 ]
Wang, Fei [3 ]
Wei, Yue [3 ]
Zhang, Ying [1 ,2 ]
Jia, Chengyong [1 ,2 ]
He, Jia [1 ,2 ]
Yao, Jinqiu [1 ,2 ]
Zhang, Zefang [1 ,2 ]
Li, Zhaoyang [1 ,2 ]
Li, Peiwen [1 ,2 ]
He, Meian [1 ,2 ,4 ,5 ]
机构
[1] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China
[3] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning 530021, Guangxi, Peoples R China
[4] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
关键词
BPA; Overweight; Obesity; Mediation; Adiponectin; ENDOCRINE-DISRUPTING CHEMICALS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; WAIST CIRCUMFERENCE; IN-VIVO; URINARY; EXPOSURE; BPA; MICE; MECHANISMS;
D O I
10.1016/j.chemosphere.2022.136287
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Existing cross-sectional studies indicated a positive association of bisphenol A (BPA) with overweight and obesity. However, the relationship and potential mechanisms underlying this association remain to be elucidated in prospective studies.Objective: This study was designed to investigate whether serum BPA is associated with incident overweight and obesity risk, and to further explore whether adiponectin plays a mediating role in the association.Methods: We measured blood BPA and adiponectin in Chinese populations. The association of serum BPA with overweight and obesity risk was evaluated using multivariable logistic regression models. We further examined the mediating effect of adiponectin by causal mediation analysis.Results: Among 796 participants free of overweight and obesity at baseline, 133 individuals developed overweight and obesity during the follow-up period. Compared with those in the lowest quartile of serum BPA, those in the second and third quartiles were positively associated with incident overweight and obesity risk adjusting for covariates (all P-values < 0.05), whereas this association was not observed in the fourth quartile. Further spline analysis showed an inverted U-shaped dose-response relationship (Pnon-linear = 0.04). Furthermore, each unit of serum log10-transformed BPA levels was associated with higher changes in waist-to-height ratio and body roundness index (all P-values < 0.05). Mediation analysis indicated significant indirect effects of adiponectin on the associations of BPA with overweight and obesity prevalence (mediation proportion: 46.08%; P = 0.02), and BMI levels (mediation proportion: 30.32%; P = 0.03).Conclusion: Serum BPA displayed a positive association with incident overweight and obesity risk in a non -monotonic pattern, and adiponectin might mediate the association. Further mechanistic studies are warranted.
引用
收藏
页数:8
相关论文
共 50 条
[41]   Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism [J].
Beyazit, Fatma ;
Hiz, Merve Meliha ;
Turkon, Hakan ;
Unsal, Mesut Abdulkerim .
GINEKOLOGIA POLSKA, 2021, 92 (10) :682-688
[42]   Association between alcohol intake, overweight, and serum lipid Levels and the risk analysis associated with the development of dyslipidemia [J].
Shen, Zhe ;
Munker, Stefan ;
Wang, Chenyang ;
Xu, Lei ;
Ye, Hua ;
Chen, Hongtan ;
Xu, Genyun ;
Zhang, Hong ;
Chen, Lihua ;
Yu, Chaohui ;
Li, Youming .
JOURNAL OF CLINICAL LIPIDOLOGY, 2014, 8 (03) :273-278
[43]   Association of exposure to Bisphenol A with obesity and cardiometabolic risk factors in children and adolescents [J].
Amin, Mohammad Mehdi ;
Ebrahim, Karim ;
Hashemi, Majid ;
Shoshtari-Yeganeh, Bahareh ;
Rafiei, Nasim ;
Mansourian, Marjan ;
Kelishadi, Roya .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2019, 29 (01) :94-106
[44]   Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity [J].
Muzzio, Maria L. ;
Kabakian, Maria L. ;
Morosan-Allo, Yanina ;
Ferrari, Silvia ;
Fallahi, Poupak ;
Fernandez, Jorgelina ;
Santucci, Maria P. ;
Andres-Lacueva, Cristina ;
Antonelli, Alessandro ;
Brenta, Gabriela ;
Merono, Tomas .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2020, 30 (07) :1188-1195
[45]   Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients - pilot study [J].
Stepien, Mariusz ;
Wlazel, Rafal N. ;
Paradowski, Marek ;
Banach, Maciej ;
Rysz, Magdalena ;
Misztal, Malgorzata ;
Rysz, Jacek .
ARCHIVES OF MEDICAL SCIENCE, 2012, 8 (03) :431-436
[46]   Impact of olive oil-rich diet on serum omentin and adiponectin levels: a randomized cross-over clinical trial among overweight women [J].
Kabiri, Akram ;
Hosseinzadeh-Attar, Mohammad Javad ;
Haghighatdoost, Fahimeh ;
Eshraghian, Mohammadreza ;
Esmaillzadeh, Ahmad .
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2017, 68 (05) :560-568
[47]   A study on the short-term effect of cafeteria diet and pioglitazone on insulin resistance and serum levels of adiponectin and ghrelin [J].
Colombo, G. ;
Bazzo, M. L. ;
Nogueira, C. L. ;
Colombo, M. D. H. P. ;
Schiavon, L. L. ;
d'Acampora, A. J. .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2012, 45 (10) :935-941
[48]   Serum leptin and adiponectin levels and their association with allergic sensitization [J].
Radon, K. ;
Schulze, A. ;
Schierl, R. ;
Dietrich-Guemperlein, G. ;
Nowak, D. ;
Joerres, R. A. .
ALLERGY, 2008, 63 (11) :1448-1454
[49]   Association of serum adiponectin and myostatin levels with skeletal muscle in patients with obesity: A cross-sectional study [J].
Kurose, Satoshi ;
Onishi, Katsuko ;
Takao, Nana ;
Miyauchi, Takumi ;
Takahashi, Kazuhisa ;
Kimura, Yutaka .
PLOS ONE, 2021, 16 (01)
[50]   Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults [J].
Ramirez-Cruz, Armando ;
Rios-Lugo, Maria Judith ;
Soto-Sanchez, Jacqueline ;
Juarez-Perez, Cuauhtemoc Arturo ;
Cabello-Lopez, Alejandro ;
Jimenez-Ramirez, Carmina ;
Chang-Rueda, Consuelo ;
Cruz, Miguel ;
Hernandez-Mendoza, Hector ;
Vazquez-Moreno, Miguel .
METABOLITES, 2024, 14 (05)