One pot synthesis of(±)/(S)-atenolol and (±)/(S)-propranolol by employing polymer supported reagent

被引：10

作者：

Damle, SV ^{[1
]}

Patil, PN ^{[1
]}

Salunkhe, MM ^{[1
]}

机构：

[1] Inst Sci, Dept Chem, Mumbai 400032, India

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 10期

关键词：

D O I：

10.1080/00397919908086148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+/-)/(S)-Atenolol and (+/-)/( S)- propranolol were synthesized by using reaction of (+/-)/(S) -epichlorchydrin with polymer supported phenoxide anion followed by reaction with isopropylamine.

引用

页码：1639 / 1644

页数：6

共 16 条

[1] LIPASE CATALYSIS IN ORGANIC-SOLVENTS - APPLICATION TO THE SYNTHESIS OF (R)-ATENOLOL AND (S)-ATENOLOL [J].

BEVINAKATTI, HS ;

BANERJI, AA .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (22) :6003-6005

[2] PRACTICAL CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF PROPRANOLOL [J].

BEVINAKATTI, HS ;

BANERJI, AA .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (18) :5372-5375

[3]

Caplar V., 1984, ANAL PROFILES DRUG S, V13, P1

[4]

DEEGAN A, Patent No. 1391444

[5]

FORD WT, 1986, POLYM REAGENTS CATAL, P12

[6] BETA-ADRENERGIC BLOCKING AGENTS .3. OPTICAL ISOMERS OF PRONETHALOL PROPRANOLOL AND SEVERAL RELATED COMPOUNDS [J].

HOWE, R ;

RAO, BS .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (06) :1118-&

[7]

Kitaori K, 1997, CHEM PHARM BULL, V45, P412

[8] ASYMMETRIC EPOXIDATION OF ALLYL ALCOHOL - EFFICIENT ROUTES TO HOMOCHIRAL BETA-ADRENERGIC BLOCKING-AGENTS [J].

KLUNDER, JM ;

KO, SY ;

SHARPLESS, KB .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (19) :3710-3712

[9]

LEDNICER D, 1980, ORGANIC CHEM DRUG SY, V2, P109

[10] ABSOLUTE-CONFIGURATION OF GLYCEROL DERIVATIVES .5. OXPRENOLOL ENANTIOMERS [J].

NELSON, WL ;

BURKE, TR .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (19) :3641-3645

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