Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning

被引：36

作者：

Dozmorov, Mikhail G. ^{[1
]}

Bilbo, Staci D. ^{[2
]}

Kollins, Scott H. ^{[3
]}

Zucker, Nancy ^{[3
]}

Do, Elizabeth K. ^{[4
]}

Schechter, Julia C. ^{[3
]}

Zhang, Junfeng ^{[5
,6
]}

Murphy, Susan K. ^{[7
]}

Hoyo, Cathrine ^{[8
]}

Fuemmeler, Bernard F. ^{[4
]}

机构：

[1] Virginia Commonwealth Univ, Dept Biostat, Med Coll Virginia Campus, Richmond, VA 23298 USA

[2] Harvard Med Sch, MassGen Hosp Children, Lurie Ctr Autism, Boston, MA 02129 USA

[3] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA

[4] Virginia Commonwealth Univ, Dept Hlth Behav & Policy, POB 980149,830 E Main St, Richmond, VA 23219 USA

[5] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA

[6] Duke Univ, Duke Global Hlth Inst, Durham, NC 27708 USA

[7] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27708 USA

[8] North Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2018年 / 70卷

关键词：

Proinflammatory cytokines; Chemokine; Cognitive abilities; NIH toolbox; Executive function; DNA METHYLATION; AUTISM; PREGNANCY; MICROGLIA; DISORDER; EXPOSURE; OUTCOMES; STRESS; CELLS; BIRTH;

D O I：

10.1016/j.bbi.2018.03.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during gestation and later cognitive ability and executive function remains understudied. Children (n = 246) were born of mothers enrolled in the Newborn Epigenetic Study - a prospective pre-birth cohort in the Southeastern US. We characterized seven cytokines [IL - 1 beta, IL- 4, IL- 6, IL- 12p70, IL- 17A, tumor necrosis factor-alpha (TNF alpha), and interferon-gamma (IEN gamma)] and one chemokine (IL- 8) from maternal plasma collected during pregnancy. We assessed children's cognitive abilities and executive functioning at a mean age of 4.5 (SD = 1.1) years. Children's DAS-II and NIH toolbox scores were regressed on cytokines and the chemokine, controlling for maternal age, race, education, body mass index, IQ parity, smoking status, delivery type, gestational weeks, and child birth weight and sex. Higher IL-12p70 (beta(IL-12p70) = 4.26, p = 0.023) and IL-17A (beta(IL-17A) = 3.70, p = 0.042) levels were related to higher DAS-II GCA score, whereas higher IL-1 beta (beta(IL-1B) = -6.07, p = 0.003) was related to lower GCA score. Higher IL-12p70 was related to higher performance on NIH toolbox measures of executive functions related to inhibitory control and attention (beta(IL-12p70) = 5.20,p = 0.046) and cognitive flexibility (beta(IL-12p70) = 5.10, p = 0.047). Results suggest that dysregulation in gestational immune activity are associated with child cognitive ability and executive functioning. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：390 / 397

页数：8

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