Imaging Depths of Near-Infrared Quantum Dots in First and Second Optical Windows

被引:74
作者
Won, Nayoun
Jeong, Sanghwa
Kim, Kangwook
Kwag, Jungheon
Park, Joonhyuck
Kim, Sang Geol
Kim, Sungjee [1 ]
机构
[1] Pohang Univ Sci & Technol, Dept Chem, Gyeongbuk, South Korea
来源
MOLECULAR IMAGING | 2012年 / 11卷 / 04期
基金
新加坡国家研究基金会;
关键词
SEMICONDUCTOR NANOCRYSTALS; CARBON NANOTUBES;
D O I
10.2310/7290.2011.00057
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Potential advantages of quantum dot (QD) imaging in the second optical window (SOW) at 1,000 to 1,400 nm over the first optical window (FOW) at 700 to 900 nm have attracted much interest. QDs that emit at 800 nm (800QDs) and QDs that emit at 1,300 nm (1,300QDs) are used to investigate the imaging depths at the FOW and SOW. QD images in biologic tissues are processed binarized via global thresholding method, and the imaging depths are determined using the criteria of contrast to noise ratio and relative apparent size. Owing to the reduced scattering in the SOW, imaging depth in skin can be extended by approximately three times for 1,300QD/SOW over 800QD/FOW. In liver, excitation of 1,300QD/SOW can be shifted to longer wavelengths; thus, the imaging depth can be extended by 1.4 times. Effects of quantum yield (QY), concentration, incidence angle, polarization, and fluence rate F on imaging depth are comprehensively studied. Under F approved by the Food and Drug Administration, 1,300QDs with 50% QY can reach imaging depths of 29.7 mm in liver and 17.5 mm in skin. A time-gated excitation using 1,000 times higher F pulses can obtain the imaging depth of approximate to 5 cm. To validate our estimates, in vivo whole-body imaging experiments are performed using small-animal models.
引用
收藏
页码:338 / 352
页数:15
相关论文
共 47 条
  • [1] [Anonymous], 2002, The Essential Physics of Medical Imaging
  • [2] Alloyed semiconductor quantum dots: Tuning the optical properties without changing the particle size
    Bailey, RE
    Nie, SM
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (23) : 7100 - 7106
  • [3] Sentinel lymph node imaging using quantum dots in mouse tumor models
    Ballou, Byron
    Ernst, Lauren A.
    Andreko, Susan
    Harper, Theresa
    Fitzpatrick, James A. J.
    Waggoner, Alan S.
    Bruchez, Marcel P.
    [J]. BIOCONJUGATE CHEMISTRY, 2007, 18 (02) : 389 - 396
  • [4] ZnTe/ZnSe (Core/Shell) Type-II Quantum Dots: Their Optical and Photovoltaic Properties
    Bang, Jiwon
    Park, Juwon
    Lee, Ji Hwang
    Won, Nayoun
    Nam, Jutaek
    Lim, Jongwoo
    Chang, Byoung Yong
    Lee, Hyo Joong
    Chon, Bonghwan
    Shin, Junghan
    Park, Jae Byung
    Choi, Jong Hwa
    Cho, Kilwon
    Park, Su Moon
    Joo, Taiha
    Kim, Sungjee
    [J]. CHEMISTRY OF MATERIALS, 2010, 22 (01) : 233 - 240
  • [5] Hyaluronic Acid-Quantum Dot Conjugates for In Vivo Lymphatic Vessel Imaging
    Bhang, Suk Ho
    Won, Nayoun
    Lee, Tae-Jin
    Jin, Ho
    Nam, Jutaek
    Park, Joonhyuck
    Chung, Hyokyun
    Park, Hyun-Seo
    Sung, Yung-Eun
    Hahn, Sei Kwang
    Kim, Byung-Soo
    Kim, Sungjee
    [J]. ACS NANO, 2009, 3 (06) : 1389 - 1398
  • [6] Semiconductor nanocrystals as fluorescent biological labels
    Bruchez, M
    Moronne, M
    Gin, P
    Weiss, S
    Alivisatos, AP
    [J]. SCIENCE, 1998, 281 (5385) : 2013 - 2016
  • [7] Quantum dot bioconjugates for ultrasensitive nonisotopic detection
    Chan, WCW
    Nie, SM
    [J]. SCIENCE, 1998, 281 (5385) : 2016 - 2018
  • [8] A REVIEW OF THE OPTICAL-PROPERTIES OF BIOLOGICAL TISSUES
    CHEONG, WF
    PRAHL, SA
    WELCH, AJ
    [J]. IEEE JOURNAL OF QUANTUM ELECTRONICS, 1990, 26 (12) : 2166 - 2185
  • [9] Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells
    Cherukuri, P
    Bachilo, SM
    Litovsky, SH
    Weisman, RB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (48) : 15638 - 15639
  • [10] Renal clearance of quantum dots
    Choi, Hak Soo
    Liu, Wenhao
    Misra, Preeti
    Tanaka, Eiichi
    Zimmer, John P.
    Ipe, Binil Itty
    Bawendi, Moungi G.
    Frangioni, John V.
    [J]. NATURE BIOTECHNOLOGY, 2007, 25 (10) : 1165 - 1170